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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- as no details on test conditions are given, it is assumed that the results relate to nominal concentartion based on test substance concentrations
- Executive summary:
Algal toxicity was determined with pseudokirchneriella subcapitata in the presence of phthalic anhydride according to the OECD TG 201. NOEC was determined as 32 mg/l and EC50 as 68 mg/l after 72h (MITI, 2003).
Reference
No information is given on pH
Description of key information
In two limit tests with and without pH adjustment, the toxicity to the fresh water algae Desmodesmus subspicatus of the hydrolysis product phthalic acid was performed according to EU Method C.3 (Algal Inhibition test). The results of both tests clearly indicate that the toxic effects are not due to substance inherent properties but to a function of pH. The test with pH adjustment gave a NOEC of > 100 mg/l (Bayer Industry Services, 2004).
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
Concerning the toxicity towards aquatic algae there is only one test with phthalic anhydride available (MITI, 2003), but should not be used for the hazard assessment, due to missing information on pH. As phthalic anhydride hydrolyses within 30.5 sec forming the main hydrolysis product phthalic acid, tests with phthalic acid are used to draw a conclusion on toxicity to aquatic algae. Algal toxicity was determined by a GLP test with Desmodesmus subspicatus in the presence of phthalic acid according to the OECD TG 201 "Algal Growth Inhibition Test". Two limit tests were conducted with each 100 mg/l with and without pH adjustment. The stability of the test substance was experimentally determined via HPLC before and after an exposure of 72 hours. The 72 h-EC0 was >/= 100 mg/l and the recovery rate was > 98 %, therefore the nominal value was reported. The results are related to both endpoints growth rate and biomass. Without pH adjustment at 100 mg/l 100 % inhibition was observed after 72 hours; pH was determined to be in the range of 4.9 to 5.1. This indicates that phthalic acid causes a pH shift in algal medium. It is the resulting pH that determines the impact of phthalic acid on algae as shown with buffered test substance solution. Thus, toxic effects are not due to substance inherent properties but to a function of the pH (Bayer Industry Services, 2004).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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