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Diss Factsheets
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EC number: 227-561-6 | CAS number: 5888-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate)
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP Publications
- Reference Type:
- other: method description
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Pregnant mice received the test compound via oral gavage on days 5 - 20 of gestation. The controls received concurrently the vehicle. Doses of n-butyl acrylate were 100, 1000, 1500, 2000, 2500, 3000, 4000 mg/kg bw/day.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl acrylate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- cotton seed oil
- Details on mating procedure:
- - Impregnation procedure: cohoused
- Duration of treatment / exposure:
- day 6 - 15 of gestation
- Frequency of treatment:
- dayly
- No. of animals per sex per dose:
- 25-30
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 2 000 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- When adminitered orally in mice at day 6 - 15 of gestation, butyl acrylate showed effects on offspring at doses highly above the threshold for maternal toxicity. The NOAEL for developmental toxicity is 1000 mg/kg based on diminished fetal body weights at 1500 mg/kg and above. The NOAEL for teratogenicity is 2000 mg/kg based on malformations observed at higher doses.
- Executive summary:
Mice obained n-butyl acrylate during day 6 -15 of gestation by oral gavage in doses of 0, 100, 1000, 1500, 2000, 3000 and 4000 mg/kg. The highest dose was lethal to all animals. At 3000 and 2500 mg/kg, 2 of 30 animals died. At 2000, 1500 and 1000 mg/kg, 1 of 30 animals died. Maternal body weight gain and fetal body weights were significantly reduced at 1500 mg/kg and higher dose groups. The percentage of resorptions was significantly increased at 2500 and 3000 mg/kg.Up to 2000 mg/kg and in the controls, sporadic malformations on different sides were observed (i.e. single cases of cleft palate, fused ribs, sternebrae, and arches, extra arches, branced ribs). There was no dose dependency with the exception of a slight increase when taking the sum of all events per dose group together. In the higher dose groups 2500 and 3000 mg/kg, a significant increase of fetuses with external and skeletal malfunctions and variations (cleft palate, exencephaly, open eyes, fused arches, fused ribs).
NOAEL (maternal): 100 mg/kg
NOAEL (developmental toxicity): 1000 mg/kg
NOAEL (teratogenicity): 2000 mg/kg
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