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EC number: 227-561-6 | CAS number: 5888-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 oral, rat: 4350 mg/kg bw
LD50 dermal, rabbit: > 30000 mg/kg
inhalation: no data available/ no relevant pathway of exposure due to the low VP
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Study conducted pre-GLP.
- Principles of method if other than guideline:
- Standard acute method. Study conducted pre-GLP.
- GLP compliance:
- no
- Remarks:
- study conducted pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Seventy male Wistar albino rats weighing between 200 and 300 g were used. The animals were fed, housed and watered in accordance with standard laboratory procedures.
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test animals were fasted for a period of app. 24 hrs prior to testing. The test material was administered as a single dosage.
- Doses:
- Control = 0, 3000, 3500, 4000, 4500, 5000, 6000 mg/kg
- No. of animals per sex per dose:
- Total number of animals: 70
10 anmals per dose - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: for mortality and toxicity immeldiately after dosing: 1, 3, 6, 24, 48, and 72 hours post-dosing; and daily thereafter for a total of 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 750 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 24 hrs
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 350 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 14 d
- Mortality:
- please see attached table
- Clinical signs:
- other: Depression, burrowing, twitching, staggering, abnormal gait, straub tail, clonic convulsions, tremors, respiratory depression, piloerection, and rates of death. Details see attached table.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information EU 1272/2008 Criteria used for interpretation of results: EU
- Conclusions:
- According to the test result: LD50(14days): 4350 mg/kg bw (male rats) the test substance Isobornyl acrylate has not to be classified with respect to acute oral toxicity (EU GHS criteria; 1272/2008/EU).
- Executive summary:
In an acute oral toxicity study according to standard acute method conducted pre-GLP, groups of fasted male Wistar rats obtained a single oral dose of Isobornyl acrylate at a doses up to 6000 mg/kg and were observed for 14 days.
Oral LD50= 4350 mg/kg bw
Isobornyl acrylate has a low acute toxic potential in rats (EU GHS: no category) based on this test.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 350 mg/kg bw
- Quality of whole database:
- reliable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Standard acute method. Study conducted pre-GLP.
- Guideline:
- other: pre-guideline
- GLP compliance:
- no
- Remarks:
- Study conducted pre-GLP.
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Twelve male New Zealand albino rabbits, in a weight range of between 2.3 and 3.0 kilograms, were used in this experiment. The animals were fed, housed, and maintained in accordance with standard laboratory procedures.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The animals were immobilized in an animal holder and the trunks clipped free of hair with an Oster animal clipper. One-half of the animals were further prepared by making epidermal abrasions every two or three centimetres longitudinally over the area of exposure. The abrasions were made sufficiently deep to penetrate the stratum corneum but not deep enough to disturb the derma. The test material was introduced over approximately 10.7 % of the animal body surface and held in contact with skin by means of a sleeve for a period of twenty-four hours at which time the sleeve was removed and the treated areas wiped clean of the remaining excess of the material.
- Duration of exposure:
- 24 hrs
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- 12
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: not reported
- Gross pathology:
- not reported
- Other findings:
- not reported
- Interpretation of results:
- GHS criteria not met
- Remarks:
- 1272/2008/EU Criteria used for interpretation of results: EU
- Conclusions:
- According to the test result: LD50(14days): > 3000 mg/kg bw (male rats) the test substance Isobornyl acrylate has not to be classified with respect to acute dermal toxicity (EU GHS criteria; 1272/2008/EU).
- Executive summary:
In an acute dermal toxicity study according to standard method conducted pre-GLP, a group of fasted male New Zealand rabbits was administered dermally a single oral dose of 3000 mg/kg body weight Isobornyl acrylate. The observation period was 14 days.
Result:
Dermal LD50 >3000 mg/kg bw
Isobornyl acrylate has a low acute toxic potential in rabbits (EU GHS: no category) based on this test.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- reliable
Additional information
Isobornyl acrylate is of low toxicity by the oral (LD50 rat = 4350 mg/kg) and dermal route (LD50 rabbit > 3000 mg/kg) in reliable pre-guideline studies.
Due to the low vapour pressure of the substance, inhalation is not considered as a relevant pathway of exposure.
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted for the acute toxicity.
According to the criteria as of UN-GHS, Cat 5 oral is warranted for the acute toxicity.
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