Registration Dossier
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EC number: 200-273-8 | CAS number: 56-41-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
L-Alanine was predicted to be readily biodegradable by using the calculation method BIOWIN (Version 4.10).
The supporting studies also indicate that L-alanine is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
L-Alanine was predicted to be readily biodegradable by using the calculation method BIOWIN (Version 4.10). The suitability of the model was assessed and it was concluded that L-alanine is considered to be inside the applicability domain of the EpiSuite BIOWIN model.
The study using the calculation method was considered the most reliable one in comparison to the other applicable studies. Thus, it was chosen as the key study.
A supporting study with DL-alanine also indicates that L-alanine is readily biodegradable. DL-alanine is rapidly oxidized in activated sludge. After only 24 h already 43% of the Theoretical Oxygen Demand were achieved. Read-across from DL-alanine to L-alanine was applied because of similar physico-chemical characteristics, a similar toxicological/ecotoxicological profile and the structural similarity of racemic alanine to the enantiomer L-alanine. One can expect that the equivalent concentrations of L-alanine will also be rapidly oxidised in activated sludge. Instead of DL-alanine, L-alanine is a natural constituent of most living cells, is involved in many metabolic pathways and more subject to undergo biodegradation.
Three other supporting studies were considered to be less reliable, because their documentation was limited. The experimental results of these three supporting studies also consistently indicate that L-alanine is readily biodegradable.
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