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EC number: 700-102-1 | CAS number: 105112-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A study was performed to test the effects of repeated doses of the test substance 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline to CD rats for 28 days
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
Additional information
Information about the repeated dose toxicity of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline is available from a valid 28-day oral dose test in CD rats that were exposed to 40, 200 or 1000 mg/kg body weight/day by gavage. A dosage of 1000 mg/kg bw/day was associated with a slight macrocytic anaemia and a dosage of 200 mg/kg bw/day or more was associated with an increase in lymphocyte and neutrophil numbers. These changes were fully recovered in a group of animals that received the high dose for 30 days and were observed for another 16 days without further exposure. The NOEL in the study was 40 mg/kg bw/day.
Justification for classification or non-classification
It is concluded that oral administration of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline to CD rats for 30 days at dosage of 1000 mg/kg/day was associated with a slight macrocytic anaemia and at 200 mg/kg/day or more with an increase in lymphocyte and neutrophil numbers. These changes were fully reversible. A classification does not apply for chronic oral toxicity of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline. This is also supported by section 3.9.2.8 in the GHS and CLP documents, where it is stated that small changes in blood chemistry would not justify classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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