Potassium iodate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various test chemicals

Justification for type of information:

Experimental data of various test chemicals is from collection of data

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE report is based on three short term toxicity study of test chemical on the mobility of aquatic invertebrates.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Details on test solutions:

1: The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively.

Test organisms (species):

other: 1: daphnia magna, 2: Dreissena polymorpha

Details on test organisms:

2: - Common name: Water flea
- Source: Own breeding of daphnia magna
- Food: No feeding after hatching

3: LIFE STAGE : Adult(s)COMMENT : 1.5-2.0 cm

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Remarks on exposure duration:

24 hrs in 3rd study

Post exposure observation period:

24 and 48 hrs

Hardness:

1: 153.5 mg of CaCO3

Test temperature:

1: 20±2

pH:

1: 7.1

2: 7

Nominal and measured concentrations:

1: 100 mg/l

Details on test conditions:

1: TEST SYSTEM
- Test vessel: Glass beaker
- Aeration: No aeration during experiment
- Material, size, headspace, fill volume: 25 ml of glass beaker filled with 20 ml media having headspace of 5 ml
- No. of organisms per vessel: 10 daphnids

Test water:
ADaM’s media is used, prepared in MiliQ water.

OTHER TEST CONDITIONS
- Photoperiod:16 hours light and 8 hours dark

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : pH, Dissolved oxygen, temperature and mobility


- Results used to determine the conditions for the definitive study: Mobility

Reference substance (positive control):

no

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 1st study

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

226 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

1: Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L.
2: The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L.

Executive summary:

Various studies for the test chemical and structurally and functionally similar read across chemical were reviewed and summarized for the determination of chemical effect on the mobility of test organisms aquatic invertebrates which are as follows:

 

The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A semi-static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be non hazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.

 

Similar study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Thus based on the above effects, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Description of key information

1: Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test material on test daphnia was determine to be > 100 mg/L.

2: The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

100 mg/L

Additional information

Various studies for the test chemical and structurally and functionally similar read across chemical were reviewed and summarized for the determination of chemical effect on the mobility of test organisms aquatic invertebrates which are as follows:

 

The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A semi-static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be non hazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.

 

Similar study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Thus based on the above effects, chemical consider to be nontoxic and not classified as per the CLP classification criteria.