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EC number: 222-883-3 | CAS number: 3648-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 > 1000 mg/L, NOEC 1000 mg/L, Dioctyltin oxide, OECD 209, Roulstone (2012).
EC50 > 1000 mg/L, NOEC 100 mg/L, Dioctylbis(pentane-2,4-dionate-O,O’)tin, OECD 209, Fiebig (2011).
Key value for chemical safety assessment
Additional information
Two studies are available for the read-across substances dioctyltin oxide and dioctylbis(pentane-2,4 -dionate-O,O')tin, which have been used to address this endpoint on a weight of evidence basis.
Roulstone (2012) performed an activated sludge respiration inhibition test using dioctyltin oxide. The study was performed under GLP conditions and to standardised guidelines. The rate of respiration was determined in the activated sewage sludge after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol. The effect of the test material on the respiration of activated sewage sludge gave a 3 hour EC50 value of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/L. It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L. No statistically significant toxic effects were shown at any of the test concentrations employed. It was therefore considered justifiable not to perform a definitive test.
Fiebig (2011) determined the effect on the respiration of activated sewage sludge micro-organisms after exposure to dioctylbis(pentane-2,4 -dionate-O,O')tin. The study was performed under GLP conditions and in line with standardised guidelines. The test was conducted under static conditions at nominal test concentrations of 10, 32, 100, 320 and 1000 mg/L with a 3 hour contact time. Under the conditions of the study the EC50 of the test material was determined to be greater than 1000 mg/L; the NOEC was determined to be 100 mg/L.
Since both studies were conducted with read across substances in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results they were assigned a reliability score of 2 according to the criteria of Klimisch (1997) and were considered suitable as an accurate reflection of the substance di-n-octyltin laurate.
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