Registration Dossier
Registration Dossier
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EC number: 426-790-0 | CAS number: 162208-27-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Ames test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- EC Number:
- 426-790-0
- EC Name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- Cas Number:
- 162208-27-7
- Molecular formula:
- Hill formula: C10 H16 N3 O5 P S2
- IUPAC Name:
- diethoxy(sulfanylidene)-lambda5-phosphanyl (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium (Strains TA98, TA100, TA1535 and TA1537) Escherichia coli (Strain CM891)
- Metabolic activation system:
- Aroclor-induced rat liver S9
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 5 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 5 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: Dimethyl sulphoxide
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 5000 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 5000 µg/plate)
- Additional information on results:
- Observations:
No increases in revertant colony numbers over control counts
were obtained with any of the tester strains following
exposure to the test substance, in either the presence or
absence of S-9 mix.
Inhibition of bacterial growth occurred in all strains
following exposure to the test substance at 5000 g/plate.
The solvent controls gave counts in the expected ranges. All
positive controls produced marked increases in the
revertant counts. - Remarks on result:
- other: other: main test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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