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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annev V
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
EC Number:
426-790-0
EC Name:
Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
Cas Number:
162208-27-7
Molecular formula:
Hill formula: C10 H16 N3 O5 P S2
IUPAC Name:
diethoxy(sulfanylidene)-lambda5-phosphanyl (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetate

Test animals

Species:
other: Rat (Sprague-Dawley origin)

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Aqueous methylcellulose
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 053 mg/kg bw
95% CL:
814 - 1 362
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
Signs of toxicity related to dose levels:
At 2000 mg/Kg all animals died or were sacrificed on humane
grounds by day 3. Two animals treated with 1000 mg/Kg/day
died within 24 hours of dosing. Clinical signs included
piloerection, hunched posture, waddling/unsteady gait,
abnormal respiration, pallid extremities, dark colouring to
eyes, lethargy, thin/ungroomed appearance, increased
sensitivity to touch, body tremors, increased salivation,
blue/cold extremities and protruding eyes among rats at all
dosages. Also observed was walking on toes and partially
closed eyelids (in rats at 2000 mg/Kg/day), increased
lacrimation (in rats at 500 and 1000 mg/Kg), abnormal
coloured urine (in rats at 500 and 2000 mg/Kg), abnormal
faeces (in rats at 1000 mg/Kg), prostration and convulsion
(clonic) and partially closed eyelids (in rats at 1000 and
2000 mg/Kg). Recovery of surviving rats was complete by Day
10.
Gross pathology:
Effects on organs:
Macroscopic examination of decedents revealed congestive
changes in the majority of organs and tissues. There were no
macroscopic abnormalities observed among animals killed at
study termination.
Other findings:
Signs of toxicity (local):
Transient slight irritation (erythema/oedema up to Grade 2)
notable in one or more animals at all dosages with
resolution complete in all instances by Day 5. This response
was accompanied by localised, patchy skin reactions
characterised by necrosis in one female and/or scabbing in
one further female.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU