Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Three Repeat Dose Studies have been conducted on the source chemical n-butyl acrylate. These results are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
13 Week Drinking Water Study in Rats:
NOAEL Males: 84/mg/kg (Highest Dose Tested);
NOAEL Females: 111mg/kg (Highest Dose Tested)
13 Week Oral Gavage Study in Rats:
LOAEL Male/Female: 150 mg/kg (Only dose tested; increased relative liver weights only)
13 Week Inhalation Study in Rats
NOAEC Systemic Effects: 108 ppm
LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only): 211 ppm
NOAEC Local: 21 ppm
LOAEC: Local (histological changes in nasal mucosa): 108 ppm
Key value for chemical safety assessment
Additional information
Three Repeat Dose Studies have been conducted on the source chemical n-butyl acrylate. These results are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
In all three tests, systemic toxicity was low; some of the effects reported as adverse may not be considered adverse. Recovery data are not available so it is difficult to decide if the effects are adverse or adaptive. The results indicate that there is low risk for adverse systemic effects based on repeated exposures. Local effects such as those seen in the inhalation study are more relevant to repeat dose toxicity.
Data matrix – Analog approach |
|||
Target substance |
Source substance (1) |
|
|
CHEMICAL NAME |
2-methylbutyl acrylate |
n-butyl acrylate |
|
CAS# |
44914-03-6 |
141-32-2 |
|
Molecular formula |
C8H14O2 |
C7H12O2 |
|
Molecular Weight |
142.2 |
128.2 |
|
PHYSICO-CHEMICAL DATA |
|||
Melting Point |
Experimental: ≤ -75 °C |
Not available |
|
Boiling Point |
Experimental: 161.7 °C at 1013hPa |
Experimental: 147 °C at 1013hPa |
|
Density |
Experimental: 0.8886 g/cm3 at 25 °C |
Experimental: 0.9 g/cm3 at 20.0 °C |
|
Vapour Pressure |
Experimental: 1.7 hPa at 20°C |
Experimental: 5 hPa at 22.2°C |
|
Partition Coefficient (log KOW) |
Experimental: 2.9 |
Experimental: 2.38 (at 25°C) |
|
Water Solubility |
Experimental: 316 mg/L at 23 °C |
Not available |
|
MAMMALIAN TOXICITY |
|||
13 Week Drinking Water Study in rats |
Readacross from source (1): NOAEL Males: 84/mg/kg (Highest Dose Tested); NOAEL Females: 111mg/kg (Highest Dose Tested) |
Experimental: NOAEL Males: 84/mg/kg (Highest Dose Tested); NOAEL Females: 111mg/kg (Highest Dose Tested) |
|
13 Week Oral Gavage study in rats |
Readacross from source (1): LOAEL Male/Female: 150 mg/kg (Only dose tested; increased relative liver weights only) |
Experimental: LOAEL Male/Female: 150 mg/kg (Only dose tested; increased relative liver weights only) |
|
13 Week Inhalation Study in Rats |
Readacross from source (1): NOAEC Systemic Effects: 108 ppm LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only): 211 ppm NOAEC Local: 21 ppm LOAEC: Local (histological changes in nasal mucosa): 108 ppm |
Experimental: NOAEC Systemic Effects: 108 ppm LOAEC: Systemic Effects (body weight decrease, clinical chemistry changes in females only): 211 ppm NOAEC Local: 21 ppm LOAEC: Local (histological changes in nasal mucosa): 108 ppm |
|
Justification for classification or non-classification
Results did not meet the criteria for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.