cis-4-tert-butylcyclohexyl acetate

Viscosity

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

viscosity

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 29 August 2012 to 02 October 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Substance ID is adequately specified with purity and isomers composition. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Test Guideline 114 (Viscosity of Liquids)

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP Compliance Programme (inspected on 10 July 2012 / signed on 30 Nov. 2012)

Type of method:

capillary viscometer (static)

Specific details on test material used for the study:

Storage condition of test material: room temperature, in the dark.

Temp.:

20°C

Parameter:

kinematic viscosity (in mm²/s)

Value:

8.37

Remarks on result:

other: +/- 0.02 mm2/s

Temp.:

20°C

Parameter:

dynamic viscosity (in mPa s)

Value:

7.83

Temp.:

40°C

Parameter:

kinematic viscosity (in mm²/s)

Value:

4.54

Remarks on result:

other: +/- 0.02 mm2/s

Temp.:

40°C

Parameter:

dynamic viscosity (in mPa s)

Value:

4.25

The results are shown in the following table:

Determination	Temperature (ºC)	Time (s)	Viscosity (mm^2/s)	Mean Viscosity (mm^2/s)	Viscosity (mPa.s)
A	20.0 ± 0.5	879	8.35	8.37	7.83
B		882	8.38
A	40.0 ± 0.5	477	4.53	4.54	4.25
B		478	4.54

Conclusions:

At 20°C, the substance is a fluid liquid. Viscosity decreases slightly with temperature.

Executive summary:

The kinematic viscosity of the test substance was measured according to the OECD 114 guideline, capillary method.

Duplicate measurements were performed at 20 and 40°C, and the mean result was retained for each temperature. Results were converted to dynamic viscosity from the density.

Reference 2

Endpoint:

viscosity

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Based on structural similarity (same isomers in a different ratio) and same density, both substances are not expected to have significantly different viscosity, with regard to Aspiration Hazard classification purpose. Therefore, the result of the study will be considered for the target substance.
Further information is included in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

reference to other study

Temp.:

20°C

Parameter:

kinematic viscosity (in mm²/s)

Value:

8.37

Temp.:

20°C

Parameter:

dynamic viscosity (in mPa s)

Value:

7.83

Key result

Temp.:

40°C

Parameter:

kinematic viscosity (in mm²/s)

Value:

4.54

Temp.:

40°C

Parameter:

dynamic viscosity (in mPa s)

Value:

4.25

Conclusions:

(from analogue) At 20°C, the substance is a fluid liquid. Viscosity decreases slightly with temperature.
The results are relevant for potential classification in AH class.

Executive summary:

The kinematic viscosity of the analogue test substance was measured according to the OECD 114 guideline, capillary method.

Duplicate measurements were performed at 20 and 40°C, and the mean result was retained for each temperature. Results were converted to dynamic viscosity from the density.

The viscosity was determined as 8.37 mm2/s at 20°C, and 4.54 mm2/s at 40°C.

A similar viscosity is anticipated for the target substance.

Description of key information

(from analogue) At 20°C, the substance is a fluid liquid. Viscosity decreases slightly with temperature.

The results are relevant for potential classification in AH class (4.54 mm2/s at 40°C).

Key value for chemical safety assessment

Viscosity:

8.4 mm²/s (static)

at the temperature of:

20 °C

Additional information

No data is available on the substance itself. However, a fully reliable experimental study, conducted according to a recognized OECD method and under GLP, is available on an analogue (mixture of isomers). As no significant difference is anticipated with the dossier monoconstituent substance, the read-across is considered justified for a key study, and the result is retained as key data for purpose of CSA.