Registration Dossier
Registration Dossier
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EC number: 617-745-8 | CAS number: 856976-65-3
Endpoint summary
Administrative data
Description of key information
The oral LD50 in Wister rats was >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Quality of whole database:
- GLP and guideline study
Additional information
Oral
The effect of the test item was determined in an acute oral toxicity study to Wistar rats according to OECD guideline 423, EU method B1 and EPA OPPTS 870.1100. A limit test was conducted with a dose of 2000 mg/kg bw. Olive oil was used as vehicle. The duration of observation following administration was at leat 14 days. The LD50 was determined to be >2000 mg/kg bw.
In a supporting study the acute oral toxicity of Bis-2,4-dimethylphenoxy-propan-1,3-ol-2 (read across) to Wistar rats was tested according to OECD guideline 423. The concentration tested was 2000 mg/kg bw. 5 females and 5 males were used. The LD50 determined was 2000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
GLP and guideline study
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for acute oral toxicity under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008 The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified for acute oral toxicity under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation No 605/2014.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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