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Diss Factsheets
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EC number: 617-745-8 | CAS number: 856976-65-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Readacross justification:
The target substance 1,3-Bis(2,6-dimethylphenoxy)propan-2-ol (856976-65-3) is a structural analogue to the source substance Bis-2,4-dimethylphenoxy-propan-1,3-ol-2 (CAS 82448-02-0) differing in the positions of the two methyl groups of the two aromatic rings. Both compounds carry the same functional groups and belong to the same chemical category.
With regard to data gaps the high degree of similarity justifies that it is adequate and scientifically justified to predict environmental fate, ecotoxicological and health hazards arising from exposure to 1,3-Bis(2,6-dimethylphenoxy)propan-2-ol by read across from the surrogate Bis-2,4-dimethylphenoxypropan-1,3-ol-2. Same functional groups show same properties or they follow a trend according to these properties. Therefore it is very unlikely that the source substance behaves different compared to the target substance. The use of read-across and intrapolation is therefore justified to fill in data gaps.
Short-term toxicity to fish
In a 96 hours short term toxicity study to Golden Orfe fishes with the related test substance Bis- 2,4 -dimethylphenoxy-propan-1,3-ol-2 (read-across) the LC50 was determined to be >1000 and < 2150 mg/L.
Short-term toxicity to aquatic invertebrates
In a short term toxicity test (48 hours) to Daphnia magna the influence of the test item on the swimming ability was determined. The measured EC50 value was 1.42 mg/L with confidence limits (95%) of 1.16 - 1.73 mg/L.
Toxicity to microorganisms
In a read across study with Bis- 2,4-dimethylphenoxy-propan-1,3-ol-2 the oxygen consumption rate was measured. The EC10, EC 50 and EC90 values were determined to be 10000 mg/L.
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