Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-745-9 | CAS number: 7300-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- EC Number:
- 230-745-9
- EC Name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- Cas Number:
- 7300-34-7
- Molecular formula:
- C10H24N2O2
- IUPAC Name:
- 3-[4-(3-aminopropoxy)butoxy]propan-1-amine
Constituent 1
- Specific details on test material used for the study:
- - Analytical purity: approximately 99%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: MUS RATTUS, Brunnthal
- Weight at study initiation: 185 + 15 g
- Diet: Herilan MRH
- Water: ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- The test substance was applied in a constant quantity with the help of an infusion pump to a 2-step blast pipe. Synthetic air (2.6 bar) was used to generate an aerosol, which was infused into the system.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 22.9, 10.01, 2.19 and 0.41 [mg/L] (nominal concentration)
3.72, 1.76, 0.81, 0.17 [mg/L] (analytic concentration) - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- according to D.J. Finney (D..J*. Finney; Probitanalysis 1971, Seite 1 - 150). Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- see table below; the animals died within 1-5 days after test item application
- Clinical signs:
- other: 3.72, 1.76 [mg/L] (analytic concentration): reddish head, dyspnea, scrubby, shaggy fur, tremor 0.81 [mg/L] (analytic concentration): accelerated respiration 0.17 [mg/L] (analytic concentration): nothing abnormal detected Surviving animals did either not
- Body weight:
- The only male animal surviving exposure to 3.75 mg/l showed a significantly reduced body weight; furthermore, males at 1.76 mg/l showed some reduction on body weight, whereas all other animals exhibited body weights similar to control animals 14 days subsequent to exposure. (see table below)
- Gross pathology:
- heart: acute dilatation
lung: strong hyperemia
kidney: some animals showed tubule necrosis
Any other information on results incl. tables
Analytic concentration |
Nominal concentration |
Mortality males |
Mortality females |
3,72 |
22,9 |
9/10 |
10/10 |
1,76 |
10,01 |
6/10 |
6/10 |
0,81 |
2,19 |
0/10 |
3/10 |
0,17 |
0,41 |
0/10 |
0/10 |
Analytic concentration |
Mean body weight d0 |
Mean body weight d7 |
Mean body weight d14 |
|||
|
males |
females |
males |
females |
males |
females |
3,72 |
186 (10) |
183 (10) |
124 (1) |
all dead |
151 (1) |
all dead |
1,76 |
179 (10) |
180 (10) |
211 (4) |
181 (4) |
238 (4) |
214 (4) |
0,81 |
179 (10) |
179 (10) |
213 (10) |
186 (7) |
266 (10) |
207 (7) |
0,17 |
182 (10) |
180 (10) |
225 (10) |
201 (10) |
269 (10) |
214 (10) |
Control |
182 (10) |
182 (10) |
218 (10) |
199 (10) |
264 (10) |
213 (10) |
The number in brackets indicates the number of animals alive at the respective time point.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.