Registration Dossier
Registration Dossier
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EC number: 230-745-9 | CAS number: 7300-34-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful for fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 464 mg/L
Additional information
For the assessment of the acute toxicity of DODA (CAS 7300-34-7) to fish experimental data are available. A non-GLP study was conducted with the test item in accordance with DIN 38 412 (1982) to determine the ability of the test substance to produce toxic effects and determine the 96 -h LC50. In this static study Leuciscus idus was used as a test organism. The study was performed using not pH-adjusted test solutions (68.1 to 464 mg/L). As the test substance causes a pH-shift to more alkaline conditions with increasing test substance concentrations, the highest test solution was also tested after pH-adjustment. The test solutions without pH-adjustment showed initial pH values between 9.6 and 10.6. However, the acceptable pH range for fish is given in the OECD TG 203 as pH 6 to 8.5. After 24 hours, this pH range is only kept in the three lowest test concentrations (≤ 100 mg/L), in the test treatment of 147 mg/L the pH value was 8.7 and the test treatment of 215 mg/L showed a pH value of 9.0, while the two highest test solutions showed initial pH values above 9.0. After 48 hours, the pH shifted to acceptable levels in all treatments. While no mortality was observed in the treatments with acceptable pH values after 24 h, all fish died in the two highest test concentrations with a high pH (> 9.0) and some abnormal behavior symptoms (i.e. gasping, tumbling) were observed in the test treatments with pH values above 8.5. No additional mortality was recorded during the remaining testing period. Therefore, it can be concluded, that the 96-h LC50 is higher than 464 mg/L at environmentaly relevant conditions (pH 4 -9; nominal, BASF AG 1984, report no. 84/12). The concentrations were not analytically verified. However, the test concentrations are assumed to be stable over the exposure period based on a sufficient water solubility, a low Henry's Law constant (7.86E-08 Pa*m³/mol, est., see IUCLID Ch. 5.4.2) and a low adsorption potential (log Kow = -2.5, meas., see IUCLID Ch.4.7; log Koc = 1.48, calc., see IUCLID Ch. 5.4.1).
In conclusion, based on the available experimental data it can be concluded that the substance is with high probability acutely not harmful for fish.
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