Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18.09 - 24.09.2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to guideline, under GLP
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Principles of method if other than guideline:
Not relevant
GLP compliance:
yes (incl. certificate)
Type of method:
gas saturation method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): R-Pantolactone
- Physical state: solid
- Storage condition of test material: at RT (20°C)

Results and discussion

Vapour pressureopen allclose all
Temp.:
15 °C
Vapour pressure:
0.3 Pa
Remarks on result:
other: measured
Temp.:
25 °C
Vapour pressure:
1.1 Pa
Remarks on result:
other: measured
Temp.:
35 °C
Vapour pressure:
3.2 Pa
Remarks on result:
other: measured
Temp.:
25 °C
Vapour pressure:
1 Pa
Remarks on result:
other: interpolated

Any other information on results incl. tables

To ensure saturation control, three different flow rates were used at each temperature. Higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Applicant's summary and conclusion

Conclusions:
Calculation of the vapor pressure of R-Pantolactone at 25 °C by interpolation based upon the
simplified Clausius-Clapeyron equation resulted in a vapor pressure of
1.0 Pa at 25 °C.
Executive summary:

During this study, the vapor pressure of the test item R-Pantolactone has been determined using the gas saturation method. The vapor pressure of R-Pantolactone was measured at test temperatures of 15 °C, 25 °C and 35 °C and was determined to be 0.3 Pa at 15 °C, 1.1 Pa at 25 °C and 3.2 Pa at 35 °C. The vapor pressure of R-Pantolactone at 25 °C was interpolated from the vapor pressure curve and was calculated to be 1.0 Pa at 25 °C.