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EC number: 416-900-5 | CAS number: 79723-02-7 TMAP
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1987-July 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and/or EC guidelines and according to GLP principles. Test substance only indicated by abbreviation; no information on test substance purity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- no information on test substance purity
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetramethylammonium hydrogen phthalate
- EC Number:
- 416-900-5
- EC Name:
- Tetramethylammonium hydrogen phthalate
- Cas Number:
- 79723-02-7
- Molecular formula:
- C12H17NO4
- IUPAC Name:
- tetramethylazanium 2-carboxybenzoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): TMAP
- Physical state: white crystalline powder
- Storage condition of test material: room temperature in sealed container
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna (UK) Limited, Wyton, Huntingdon, Cambridgeshire.
- Age at study initiation: approximately ten to fourteen weeks old
- Weight at study initiation: males 234 - 269g, females 208 - 232g
- Fasting period before study: no
- Housing: solid-floor polypropylene cages with sawdust bedding; during exposure housed individually after in groups of 5 by sex.
- Diet: free access to food (Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, Witham, Essex, U.K .)
- Water: free access to mains drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 22
- Humidity (%): 60 - 68
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 16 June 1987 To: 30 June 1987
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: moistened with distilled water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6 cm x 12 cm (clipped free of hair).
- % coverage: approximately 10% of the total body surface area
- Type of wrap if used: surgical gauze measuring 7 cm x 4 cm was placed over the treatment area and semi-occluded with a double layer of elastic adhesive bandage {ELASTOPLAST) wrapped around the trunk of the rat.
REMOVAL OF TEST SUBSTANCE
- Washing: treated skin and surrounding hair was wiped with moist absorbant paper to remove any residual test material .
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed for overt signs of toxicity and mortality 1 and 4· hours after dosing and subsequently at least once daily for fourteen days. Individual bodyweights were recorded on the day of treatment (day 0) and on days seven and fourteen.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: No signs of systemic toxicity or skin irritation were noted during the study period.
- Gross pathology:
- No abnormalities were noted at necropsy of animals killed at the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on an acute dermal toxicity test with TMAP faccording to OECD guideline 402, the acute dermal median lethal dose (LD50) of TMAP in the rat was found to be greater than 2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study in rat performed according to OECD guideline 402, TMAP was tested in 5 rats/sex at the limit dose of 2000 mg/kg bw (semi-occluded application) for 24 hours. No deaths occurred. No signs of systemic toxicity or skin irritation were noted during the study. The animals showed expected gains in bodyweight over the study period. No abnormalities were noted at necropsy of animals killed at the end of the study period. The acute dermal median lethal dose (LD50) of the test material in the rat was found to be greater than 2000 mg/kg bodyweight.
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