Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-482-4 | CAS number: 17465-86-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 of the read-across substance .alpha.-cyclodextrin is > 150 mg/L (nominal).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 150 mg/L
- EC10 or NOEC for freshwater algae:
- 150 mg/L
Additional information
The read-across approach based on grouping of substances (category approach) is used due to the following reason: .alpha.-, .beta.- and .gamma.-cyclodextrin consist ofα-D-glucopyranoside units in a ring structure of 6, 7, and 8 units, respectively. Water solubility of these compounds is between 18 and 232 g/L at 25°C. The typical biodegradation route is a ring opening in the first step and then cleavage to oligo- or mono-saccharide units and further metabolisation to CO2. All degradation intermediates are practical nontoxic. Bioaccumulation is not expected due to the log Pow values ranging from -12.02 up to -7.77. The study using the test item alpha.-cyclodextrin is chosen as key study due to a similar water solubility compared with .gamma.-cyclodextrin whereas the water solubility of .beta.-cyclodextrin is significantly lower.
The influence of the read-across substance .alpha.-cyclodextrin on the growth of the freshwater green algae Pseudokirchneriella subcapitata was assessed in a static limit test (OECD 201). The 72-hours NOEC was determined to be >=150 mg test item/L. The 72-hours LOEC was > 150 mg test item/L. This value could not be quantified due to the absence of toxicity of .alpha.-cyclodextrin up to the test concentration of 150 mg test item/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
