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Diss Factsheets
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EC number: 241-482-4 | CAS number: 17465-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Based on the assessment described in the subsections above the submission substance is not a PBT / vPvB substance.
- Likely routes of exposure:
The mean biodegradation of .alpha. -Cyclodextrin was 89% (ThODNH4); the 10 day window criterion was passed. The substance is non hazardous and did not show any negative effects on aquatic organisms in the acute tests (acute fish toxicity LC50 > 200 mg/L , acute daphnia toxicity EC50 >= 100 mg/L).
Also, the read-across test substance .beta.-cyclodextrin had no toxic effects on survival and reproduction of the Daphnia magna after an exposure period of 21 days up to the highest test concentration of 120 mg/L, therefore there is no evidence for long-term aquatic toxicity. The read-across approach was applicable due to the following reason: α-, ß-, and γ-Cyclodextrins consists of α-D-glucopyranoside units in a ring structure of 6, 7, or 8 units, respectively. Water solubility of these compounds will be found between 18 and 232 g/L at 25°C. The typical biodegradation route is a ring opening in the first step and then cleavage to oligo- or mono-saccharide units and further metabolisation to CO2.
The log Kow is -12.02 (calculated).
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