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EC number: 257-077-0
CAS number: 51240-95-0
tested in a single dermal application to rats. The application was
performed with the undiluted test substance at the dose of 2000 mg/kg,
taking into consideration that its specific gravity was 0.89. The test
site was then covered by a semi-occlusive dressing for 24 hours.
Clinical signs, mortality and body weight gain were checked for a period
of 14 days following the single application of the test substance. All
animals were subjected to necropsy.
No death occurred at 2000 mg/kg. No clinical
signs were observed. The body weight gain of one female was reduced
between day 1 and 15 and another female lost weight during this same
period. The overall body gain of the other animals was not affected by
treatment with the test substance. No cutaneous reactions were observed.
No apparent abnormalities were observed at necropsy.
Under these experimental conditions, the
dermal LD0 of the test substance
tert-Butylperoxy-3,5,5-trimethylhexanoat is equal to or higher than 2000
mg/kg in rats.
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