Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-372-6 | CAS number: 39236-46-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Brief report of acute toxicity screening test: limited experimental detail and no test laboratory information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single dose toxicity screen using 1 rabbit and 3 rats.
- GLP compliance:
- no
- Remarks:
- Pre-GLP study
- Limit test:
- no
Test material
- Reference substance name:
- N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
- EC Number:
- 254-372-6
- EC Name:
- N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
- Cas Number:
- 39236-46-9
- Molecular formula:
- C11H16N8O8
- IUPAC Name:
- N',N'''-methylenebis{1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
Constituent 1
Test animals
- Species:
- other: Rabbit and rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1 male rabbit, 3 female rats
Administration / exposure
- Route of administration:
- other: Rabbit injected intravenously, rats injected intraperitoneally
- Vehicle:
- water
- Details on exposure:
- Aquepus 50% solution of test substance injected.
- Doses:
- Rabbit: 2000 mg/kg.
Rats: 1000, 2000 and 4000 mg/kg - No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Rabbit: transient pain reaction and raised body temperature, recovered one day after dosing.
- Sex:
- female
- Dose descriptor:
- other: lethal dose
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Rat: no death at 1000 or 2000 mg/kg but animal dosed at 4000 mg/kg died within 21h of dosing.
- Mortality:
- Rabbit: no death in single animal dosed at 2000 mg/kg.
Rat: the single animal dosd at 4000 mg/kg died within 21h. - Clinical signs:
- Ataxia, lethargy, abnormal posture seen in all 3 test rats.
Applicant's summary and conclusion
- Conclusions:
- Inravenous injection of test substance at 200 mg/kg was not lethal to a single test rabbit. One rat injected intraperitoneally at 4000 mg/kg died.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
