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Diss Factsheets
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EC number: 284-183-4 | CAS number: 84803-57-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study available as unpublished report. Limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- other: Summary Report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- EpiDerm corrosivity-test in vitro
- GLP compliance:
- no
Test material
- Reference substance name:
- (4-tert-butyl-2,6-dimethylphenyl)acetonitrile
- EC Number:
- 284-183-4
- EC Name:
- (4-tert-butyl-2,6-dimethylphenyl)acetonitrile
- Cas Number:
- 84803-57-6
- Molecular formula:
- C14H19N
- IUPAC Name:
- 2-(4-tert-butyl-2,6-dimethylphenyl)acetonitrile
- Details on test material:
- - Name of the test substance used in the study report: 2,6-Dimethyl-4-tert.-butylbenzylcyanid
- pH: ca. 5
Constituent 1
Test animals
- Species:
- other: EpiDerm™ tissues (reconstructed three dimensional human epidermis model)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: negative and positive controls
- Duration of treatment / exposure:
- 3 minutes and 1 hour
- Number of animals:
- 2 tissues per application time
- Details on study design:
- Two EpiDerm tissue samples were incubated with the test substance for 3 minutes and 1 hour, each. Tissue destruction was determined by measuring the metabolic activity of the tissue after exposure using a colorimetric test. The reduction of mitochondrial dehydrogenase activity, measured by reduced formazan production after incubation with a tetrazolium salt (MTT) was chosen as suitable endpoint. The formazan production of the test substance treated epidermal tissues is compared to that of negative control tissues. The quotient of both values indicates the relative tissue viability.
The tissue viability was calculated by reading Optical Densities (OD) using a spectrophotometer at 570 nm wavelength.
EVALUATION OF RESULTS
A chemical is considered as "corrosive", if the mean relative tissue viability after 3 min treatment with a test material is decreased below 50%. In addition, those materials with a viability of ≥ 50% after 3 min treatment are considered as "corrosive" if the mean relative tissue viability after 1 hour treatment with a test material is decreased below 15%.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: viability [% of NC]
- Value:
- 108
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Remarks: corrosion, exposure: 3 min, mean OD570: 2.312. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability [% of NC]
- Value:
- 108
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Remarks: corrosion, exposure 1 hour, mean OD570: 2.725. (migrated information)
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Conclusions:
- Under the conditions of the test the substance is considered to be not corrosive to the skin.
- Executive summary:
The corrosive potential was determined in an EpiDerm™ Corrosivity-Test in vitro. Two EpiDerm™ tissue samples were incubated with the test substance for 3 minutes and 1 hour, each. Tissue viability was determined after exposure to the test substance. There was no decrease in tissue viability observed after 3 minute or 1 hour exposure. Based on these results the test substance was considered to be non-corrosive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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