Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-707-7 | CAS number: 124-64-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of anti-flame treating agents on the skin
- Author:
- Aoyama M
- Year:
- 1 975
- Bibliographic source:
- Nagoya Med. J., vol 20, No. 1, 11-19
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Chemical was applied to the dorsal skin of rats every day during 20 days, and the changes were observed.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- EC Number:
- 204-707-7
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- Cas Number:
- 124-64-1
- Molecular formula:
- C4H12O4P.Cl
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium chloride
- Details on test material:
- - Name of test material (as cited in study report): tetrakis (hydroxymethyl) phosphonium chloride (THPC)
no other data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: white
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 20 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15, 20 and 30 %
Basis:
- No. of animals per sex per dose:
- 4 males per dose
- Control animals:
- yes
- Details on study design:
- The test item was applied with a brush to cervico-dorsal region of the rats. A volume of 0.75 ml was applied to 3 x 3 cm unshaved area of the cervicodorsal skin once a day, for 20 days. It was observed wether the application of each agent would cause any skin reactions or not and how intense they would be.
Results and discussion
Results of examinations
- Details on results:
- Group A (15 %): The application of the test agent (THPC) caused redness on the 4th day, but because of marked loss in body weight of the animals, the application was discontinued on the 8th day, and the animals were sacrificed and necropsied on the 12th day of beginning of application. Inconsistency between text and table: the table in the publication provides observation results for this group also on days 12 to 20.
Group B (20 %): The animals of Group B showed similar responses to those of Group A.
Group C (30 %): The application of THPC caused slight redness to manifest on the second day, and this skin reaction was intensified on the 6th day; partial falling-off hair occured on the 7th day; the application of the test agent was discontinued on the 8th day, but all animals of this group showed marked losses of body weight and eventually died 9 days after the beginning of the application.
Control (distilled water): no skin reaction at all throughout the course of the experiment.
The histopathologic examinations showed that the THPC caused atrophy or enhanced keratinization of the epidermis and degenaration of hair roots to occurred in all of group A, B and C.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
