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EC number: 204-707-7 | CAS number: 124-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for transported intermediates, calculation of PNEC is not necessary. Therefore no exposure assessment is conducted as such and PNEC derivation are not necessary as these information will not be used in a risk assessment.
Some information is available on THPC (toxicity to invertebrates and algae) but for invertebrates the results cannot be considered as reliable. Therefore the results obtained with THPS, the sulphate salt, on the most sensitive invertebrate species is used as read across with THPC.
The most sensitive species for acute toxicity isA. tonsa, tested according the ISO standard14669. The 48h-LC50is 0.46mg/L (nominal, as anhydrous active substance). It can be concluded that THPS is very toxic to aquatic invertebrates.
The influence of THPC on the growth of the marine algae Skeletonema costatum was investigated in a 72 hour static test according to the ISO Guideline No.10253 and the GLP.
The 72 hour EC50 values for the two test parameters “growth rate” and “biomass” were determined to be 0.424 mg/L and 0.12 mg/L,respectively. The 72 hour NOEC was 0.025 mg/L for both parameters.
The validity criteria requested by the ISO Guideline No.10253 were fulfilled.
This toxicity is in the same range as the highest toxicity observed with THPS on algae (ErC50= 0.122 mg/L)
Finally, by analogy with THPS we could expected that fish is not the trophic level the most sensitive (the 96h-LC50, based on mortality, ranged from 65 mg/L (Pleuronectes platessa, nominal, as main ingredient, seawater) to 75 mg/L (Lepomis macrochirus, measured as anhydrous active substance, freshwater).
Based on these results,THPC should be considered as very toxic to aquatic algae. This result is supported by the THPS data described above. In conclusion, as THPC is readily biodegradable (see section 5.2) and is considered as not potentially bioaccumulable (based on a calculated log Kow= -9.7), and considering a toxicity to algae with a EC50 < 1 mg/L, THPC is considered as very toxic for aquatic compartment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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