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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 447-830-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study planned
- Study period:
- The results should be available as soon as possible after ECHA's approval.
- Justification for type of information:
- CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Available GLP studies: There are no GLP studies available for this endpoint.
- Available non-GLP studies: There are no non-GLP studies available for this endpoint.
- Historical human data: There are no historical human data available for this endpoint.
- (Q)SAR: For this endpoint there is limited availability of (Q)SAR models whose scientific validity has been established, particularly with applicability domains relevant this type of substance. For UVCB substances the documentation from such a prediction may not prove adequate or reliable and the results may not be sufficient for classification, labelling and risk assessment purposes.
- In vitro methods: No validated in vitro methods are available for this endpoint.
- Weight of evidence: There is insufficient data to use a weight of evidence approach to fulfil this endpoint under Annex IX.
- Grouping and read-across: UVCBs pose challenges for hazard evaluation and for judging adequacy of read-across between similar complex substances for data gap filling. Data is not available for the higher tier studies and therefore this data gap remains without an adequate testing proposal.
- Substance-tailored exposure driven testing: Exposure-based waiving of some tests may be permitted in cases where it can be shown that exposure is insignificant or absent for the substance concerned. The substance is not used or transported under strictly controlled conditions throughout the life-cycle and the potential for human contact exists. Therefore exposure-based waiving is not applicable.
- Testing is not technically possible: There are no physical-chemical properties that would suggest that the performance of this test is not technically possible.
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Column 2 outlines the rules for adaptation of the tests specified in Column 1. In the case of the proposed pre-natal developmental toxicity study required under Annex IX, no adaptation is available for this endpoint.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed: In accordance with the principles of reduction, refinement and replacement, the proposed pre-natal developmental toxicity study, will be performed in one species, the rat, via the most appropriate route of administration and having regard to the likely route of human exposure. The test proposed will be performed according to OECD Test Guideline 414 as specified in Column 1 of Annex IX.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Test material
- Reference substance name:
- -
- EC Number:
- 447-830-3
- EC Name:
- -
- Molecular formula:
- Not applicable to this UVCB substance.
- IUPAC Name:
- 2-ethylphenol; 3,5-dimethylphenol; formaldehyde; phenol
- Test material form:
- other: Solid resin
- Details on test material:
- - Name of test material (as cited in study report): SF-resin (other names: Resin SF-281, SF-281, Resorcinol- formaldehyde resin, Alkyl resorcinol-formaldehyde resin)
- EC number: 447-830-3
1
Test animals
- Species:
- rat
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.