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EC number: 425-150-8 | CAS number: 94723-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with analytical monitoring
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 425-150-8
- EC Name:
- -
- Cas Number:
- 94723-86-1
- Molecular formula:
- C15 H22 O3 S
- IUPAC Name:
- 2-butanoyl-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one
- Details on test material:
- - Name of test material (as cited in study report): 625-Triketone
- Physical state: solid
- Analytical purity: 99.8% (area-%)
- Lot/batch No.:LJ 27 881/1
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Separately for each concentration 0.0469, 0.1015, 0.2190, 0.4701 and 1.00 g test substance were added to the test water using an ultra-turrax stirrer. Subsequently the fish were placed into the aquarla within 30 min after the test material was added.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: Charles River Aquatics Someren, Netherlands
- Length at study initiation: 3.16 cm (range: 2.7 - 3.6)
- Weight at study initiation: 0.34 g (range: 0.2 - 0.5)
- Feeding during test
- Food type: Standard feed (TETRA MIN), on workdays generally additionally live artemia
- Amount: ad libitum
- Duration of housing: about 2 months
ACCLIMATION
- Conditions equivalent to housing
- Health during acclimation (any mortality observed): none mortality during the last 14 days prior to test initiation
- Medical treatment: none
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 mmo/L
- Test temperature:
- 23 °C
- pH:
- 8.1 - 8.5
- Dissolved oxygen:
- 8.2 - 9.2 mg/L
- Nominal and measured concentrations:
- - Nominal test concentrations: control, 4.64, 10, 21.5, 46.4, 100 mg/L
- The analytically detected concentrations were initially in the range of 68.0% - 86.9% and after about 96 h between 90.5% - 103.3% of the nominal concentration. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, fill volume: all-glass aquaria, 30 x 22 x 24 cm, 10 L
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.34 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: municipal water, not chlorinated, passed through a charcoal filter and aerated
- Alkalinity: about 5.5 mmol/L
- Culture medium different from test medium: no
- Intervals of water quality measurement: pH and oxygen content after 1, 24, 48, 72, 96 h
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours darkness
EFFECT PARAMETERS MEASURED: mortality and symptoms after 1, 4, 24, 48, 72, 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.2
- Range finding study: yes
- Results used to determine the conditions for the definitive study: LC50 (96 h) between 10 and 100 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 4.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Lethal effect concentrations based on measured concentrations:
LC0 (96 h) = 4.2 mg/L
LC50 (96 h) = 22 mg/L
LC100 (96 h) = 100.1 mg/L
- Detected symptoms: none
- Mortality of control: none
- Small amounts of test substance on the water surface and slight sedimentation was visible in all concentrations, increasing with the increase in the concentrations.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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