Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information
The obtained results are disregarded as the substance is out from the applicability domain of the model.
Link to relevant study records
Reference
Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: other: not applicable
Type of information:
(Q)SAR
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study results are disregarded as the substance is out of the the Applicability Domain (AD) of the model.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: General model for estimating the mutagenicity
Principles of method if other than guideline:
no data
GLP compliance:
no
Type of assay:
other: QSAR
Species / strain:
other: not applicable
Metabolic activation:
not applicable
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Model assessment: Prediction is "mutagenicity = negative", but the result may be not reliable as only moderately similar compounds with known experimental value in the training set have been found.

Details are provided in attachment on the section: "attached full study report".

Conclusions:
Interpretation of results (migrated information):
negative

The obtained results are disregarded as the substance is out from the applicability domain of the model.
Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Additional information from genetic toxicity in vitro:

Justification for selection of genetic toxicity endpoint
The obtained results are disregarded as the substance is out from the applicability domain of the model.

Justification for classification or non-classification

The obtained results are disregarded as the substance is out from the applicability domain of the model. Therefore, the substance is data lacking for this endpoint.