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Diss Factsheets
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EC number: 609-106-7 | CAS number: 35249-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results have been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolates, methyl, ethyl, propyl, and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and tea-lactates, methyl, ethyl, isopropyl, and
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 998
- Bibliographic source:
- International Journal of Toxicology, 17(Suppl. 1):1-3.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Eytex assay
- Principles of method if other than guideline:
- The basis for Eytex assay is a specialized protein reagent whose conformation and hydration are altered when exposed to a chemical irritant. Protocols used were MPA (not defined), UMA (upright membrane assay), and RMA (rapid membrane assay). A direct comparison to the Draize scale was made to determine Ocular Safety Classifications and was expressed as an Eytex/Draize Equivalent (EDE) score
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic Acid
- IUPAC Name:
- Glycolic Acid
- Test material form:
- not specified
- Details on test material:
- Glycolic acid in various cosmetic formulations.
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Any other information on results incl. tables
Product type | Conc. (%) | pH | Protocol | Eyetex class | EDE | Conclusion |
70% Aq. |
||||||
Body lotion | 2,86 | 3,8 | UMA | Mild moderate | 26,5 | Mild-moderate-irritant |
Face cream | 5,71 | 5,35 | RMA | Minimal | 10,6 | Minimal irritant |
Lipline gel | 7,04 | 3,9 | UMA | Mild moderate | 31 | Mild-moderate irritant |
Hand and body lotion | 8,57 | 3,89 | UMA | Mild moderate | 31,5 | Mild-moderate irritant |
Body lotion | 11,42 | 3,5 | MPA | Moderate | 24 | Moderate-severe irritant |
Body lotion | RMA | Severe | 50,2 | Moderate-severe irritant | ||
Body lotion | 11,42 | 3,5 | MPA | Moderate | 49,5 | Moderate-severe irritant |
Body lotion | RMA | Severe | 54,1 | Moderate-severe irritant | ||
Body lotion | 11,42 | 3,5 | MPA | Moderate | 51,9 | Moderate-severe irritant |
Body lotion | RMA | Severe | Not | Moderate-severe irritant | ||
Face cream | 11,42 | 3,75 | RMA | Moderate severe | 43,3 | Moderate-severe irritant |
Body lotion | 11,42 | 3,78 | MPA | Moderate | 54 | Moderate-severe irritant |
Body lotion | RMA | Severe | 47,3 | Moderate-severe irritant | ||
Face cream | 11,42 | 5,5 | RMA | Minimal mild | 13,1 | Minimal-mild irritant |
Lipline gel | 14,08 | 3,89 | UMA | Moderate severe | 46 | Moderate-severe irritant |
Body lotion | 14,29 | N/A (50% EtOH) | UMA | Moderate severe | 49,6 | Moderate-severe irritant |
Body lotion | 14,29 | 3,6 | MPA | Moderate | 51,2 | Moderate-severe irritant |
Body lotion | RMA | Severe | 54 | Moderate-severe irritant | ||
Body lotion | 14,29 | 3,65 | MPA | Moderate | 51,6 | Moderate-severe irritant |
Body lotion | RMA | Severe | 54 | Moderate-severe irritant | ||
Body lotion | 14,29 | 3,65 | MPA | Moderate | 54 | Moderate-severe irritant |
Body lotion | RMA | Severe | Not | Moderate-severe irritant | ||
Lipline gel | 14,29 | 3,77 | MPA | Severe | 51 | Severe irritant |
Lipline gel | RMA | Severe | Not | Severe irritant | ||
Hand and body lotion | 14,29 | 3,82 | UMA | Moderate severe | 51 | Moderate-severe irritant |
Lipline gel | 14,29 | 4,01 | MPA | Moderate | 37,4 | Moderate irritant |
Lipline gel | RMA | Moderate | Not | Moderate irritant | ||
99% pure | ||||||
Face lotion | 8,08 | 3,70-3,90 | UMA | Moderate severe | 48,5 | Moderate-severe irritant |
Applicant's summary and conclusion
- Conclusions:
- Glycolic acid, as tested in the above cosmetic formulations, resulted mainly "moderate-severe irritant".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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