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EC number: 238-063-3 | CAS number: 14206-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The free acid was tested for skin and eye irritation in several studies (OECD SISDS SIAM 19). The substance caused mild to moderate irritationto skin under occlusive and semi-occlusive conditions. Application of the free acid into the conjunctival sac of the eye (OECD 405) caused moderate opacitiy, conjunctivitis and swelling. Corneal effects were not reversible within the 14 day observation period. It is expected that the sodium salt is less irritating than the free acid. Therefore the overall conclusion is "irritating to eyes".
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Reasons for read across
The test item is the sodium salt of the tested free acid. Data on the free acid is considered the worst case scenario due to the lower pH. Therefore, it is acceptable to derive irritation hazard from the free acid.
Statement of irritation potential (OECD SIDS SIAM 19)
In a skin irritation study performed under semi-occlusive conditions according to OECD TG 404, the moistened test substance was slightly irritating to the skin of rabbits (Draize scores of 0.3 each for erythema and edema). Very slight erythema and edema (both barely perceptible) were observed 1 hour and 24 hours after removal of the patches. The effects were completely reversible within 48 hours.
In another study, when the substance was applied to guinea pigs as a 12% solution in a mixtures of acetone and olive oil, and held in contact with the skin for 24 hours under occlusive conditions, the skin became edematous, necrotic, and there was some subcutaneous hemorrhage. In three guinea pigs, treated similiarly with 5-20 ml/kg of a 10% solution in a mixture of acetone and corn oil, it produced from slight to moderate irritation up to necroses, depending on the dose. Due to the use of acetone in the vehicle, this study is not considered for classification.
In an eye irritation study performed according to OECD TG 405, the moistened test substance (BONA free acid) caused serious damage to the eyes of rabbits. 1 hour after application, swelling and conjunctival injection as well as secretion (clear, tinted by the test substance) were observed in all three animals. At 24, 48 and 72 hours, conjunctivitis and diffuse corneal opacities were found. One animal showed iritis at 24 and 48 hours. Mean Draize scores (24-72 h): corneal opacity: 1.1, iris: 0.2, conjunctivitis: 1.9, conjunctival swelling: 1.3. At 7 days after the application, corneal erosion and vascularization were observed in all animals. The effects were not reversible until study end (14 days after treatment).
Conclusion
Moistened 3-hydroxy-2-naphthoic acid was slightly irritating to the skin of rabbits in a test performed according to OECD TG 404. Skin necroses and subcutaneous hemorrhages were observed in guinea pigs after occlusive exposure for 24 hours to the 10-12% solution in a mixture of acetone and olive oil or corn oil.
The substance caused serious damage to the eyes of rabbits in a test performed in accordance with OECD TG 405 (corneal vascularization / opacity).
For the sodium salt, the irritation effects are assumed to be less severe, so the effects are predicted to be reversible within 21 days.
Effects on eye irritation: irritating
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as irritating for skin under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC. It is classified as irritating to eyes.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is considered to be classified for eye irritation under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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