Ethyl diphenylphosphinite

Endpoint summary

Description of key information

Oral:
Rat LD50 male = 681mg/kg b.w., female = 316mg/kg b.w. (BASF 1982, acc. to OECD401)
Inhalation (Vapor):
Rat: LC0 >= saturated air (BASF 1982, inhalation risk test)
I.p.
Rat: LD50 male= 1002mg/kg b.w., female = 508mg/kg b.w. (BASF 1982)

Additional information

In an acute oral toxicity study according to OECD401 (BASF AG 1982), 5 male and 5 female fasted Wistar rats per dose were given a single oral dose of 681, 464, 316, or 215mg/kg in 0.5% CMC in water by gavage. The animals were observerd for 14 days and necropsy was performed. All females of the two highest doses died within 1 or 2 days, 3 males of the highest dose, 2 females receiving 316mg/kg b.w. and 1 female of the lowest dose died within 1 day after application. The expected body weight gain was observed during the study. Signs of toxicity included dyspnoe, apathy, staggering gait, impaired general state in all groups, abnormal position, atony, tonic cramps, piloerection, exsiccosis , exophthalmus in some groups, and no corneal reflex, no pain reflex, anaesthesia-like state in females in the two mid dosages. Discoloration (whitish grey to clay colored) of liver and kidney were noted in the animals that were found dead. Marks on the peripheral lobuli of the liver in 2 surviving males receving 464mg/kg were diagnosed as lipophanerosis during histopathological examination. No further abnormalities were noted. Thus the oral LD50 value for this substance is 681mg/kg b.w. for males and 316 mg/kg b.w. for females, or 456mg/kg b.w. for males and females combined.

In an acute inhalation risk test (BASF 1982), young adult Wistar rats (3 males and 3 females) were exposed to a saturated substance/air mixture for 7h, that was generated by bubbling air through a 5cm column of the liquid substance. The concentration was calculated to be <0.04mg/l via weight loss of inserted substance. The animals were observed for 14 days. No signs of systemic toxicity were observed in the animals. No abnormalities were noted at necropsy of animals sacrificed at the end of the study.

In an acute toxicity study (BASF AG 1982), 5 male and 5 female fasted Wistar rats per dose were injected intraperitoneally with a single of 1210, 825, 562, or 383mg/kg in 0.5% CMC in water. The animals were observerd for 14 days and necropsy was performed. All females of the two highest doses, 4 females receiving 562mg/kg b.w., 4 males of the highest dose, and 1 male of the second highest dose died mostly within 1 or 2 days after application. The expected body weight gain was observed during the study. Signs of toxicity in the three highest dose groups were dyspnoe, apathy, aggressivness, abnormal position, staggering gait, atony, cramps, piloerection, exsiccosis, exophthalmus, salivation, bad general state, no corneal reflex, no pain reflex, and anaesthesia-like state. The lowest dose only showed piloerection in both sexes. Animals found dead showed intraabdominal deposits of test substance and frequently a slight aszites. No abnormalities were noted at necropsy of animals sacrificed at the end of the study. Thus the LD50 value after i.p. injection for this substance is 1002mg/kg b.w. for males and 508 mg/kg b.w. for females, or 713mg/kg b.w. for males and females combined.

Justification for classification or non-classification

Based on the results of the available studies, ethyl diphenylphosphinite has to be classified as hazardous after oral uptake and labelled with R22 according to 67/548/EEC and H302 (acute toxicity oral, category 4) according to CLP/EU-GHS requirements.