Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-321-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc was tested for in vitro skin and eye corrosion properties according to OECD guideline 431 (2004) and 437 (2009), respectively. The test substance did not show any skin or eye irritation properties.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
Two tissues of the human skin model EpiDermTM were treated with Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc for three minutes and one hour, respectively. In average, 25.1 mg of the solid test item were applied to each tissue and spread to match the tissue size.
Deionised water was used as negative control, 8 m KOH was used as positive control. After treatment with the negative control the absorbance values were well above the required acceptability criterion of mean OD > 0.8 for both treatment intervals thus showing the quality of the tissues. The positive control showed clear corrosive effects for both treatment intervals. After three minutes treatment with the test item, the relative absorbance values were increased to 102.5 %. This value is well above the threshold for corrosion potential (50%). After one hour treatment, relative absorbance values were increased to 112.5 %. This value, too, is well below the threshold for corrosion potential (15%). Therefore, Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc is considered not corrosive in the Human Skin Model Test.
Eye Irritation
This in vitro study was performed to assess the corneal irritation and damage potential of Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc by quantitative measurements of changes in opacity and permeability in a bovine cornea. The test item Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc was brought onto the cornea of a bovine eye which previously had been incubated with cMEM without Phenol red at 32±1°C for one hour and whose opacity had been determined. The test item was incubated on the cornea for 4 hours at 32±1°C. After removal of the test item, opacity and permeability values were measured. Physiological sodium chloride solution was used as negative control, imidazole (20% solution in 0.9% sodium chloride solution) was used as positive control. The positive control induced a very severe irritation on the cornea, mean IVIS was 94.6580. The negative control showed no irritation, mean IVIS was 0.6500. The test item was tested pure. A mean IVIS of 0.5950 was calculated, corresponding to a classification as not eye irritant. The applied amount of test item did not show any correlation to the calculated IVIS. No observations were made which might cause doubts concerning the validity of the study outcome. The test is considered valid.
Justification for classification or non-classification
Based on data available on irritation/corrosion properties, Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc was not classified and labelled according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.