Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-206-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48 h LC0 of the test material to Daphnia magna was considered to be 50 mg/L based on read)-across to data obtained for a comparable substance
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Synthetic inositol phosphates are composed of a mix of inositol phosphates (25.0 – 38.4%) and orthophosphoric acid (23.8 – 26%). The toxicity
of this test material to Daphnia can therefore be determined based on data on these two components :
- Inositol phosphates: A study conducted on the test material (‘Inositol phosphates from rice bran’) containing a comparable amount of inositol phosphates (26.8 - 29.1%) but less orthophosphoric acid (0.4 – 1%) yielded an estimated 48 h LC0 for Daphnia magna = 50 mg/L (calculated from total organic carbon analysis results, taking into account test material settling during the study related to hardness of the daphnia medium). Read-across between the two substances is considered possible as their inositol phosphate content and physico-chemical properties (e.g. water solubility, log Kow, melting/freezing point, boiling point, relative density and surface tension) were shown to be in comparable ranges.
- Orthophosphoric acid: According to the IUCLID 2000 dataset (http://ecb.jrc.ec.europa.eu/IUCLID-DataSheets/7664382.pdf), toxicity to Daphnia of orthophosphoric acid is related to pH, not to the substance itself. Because the presence of orthophosphoric acid in ‘Synthetic inositol phosphates’ does not significantly alter the pH compared to ‘Inositol phosphates from rice bran’ (both substances have a pH <1 in undiluted form), no difference in toxicity specifically due to orthophosphoric acid is expected. Orthophosphoric acid has been shown to present low toxicity to fish, with a 96 h LC50 for mosquito fish = 138 mg/L (http://www.hillbrothers.com/msds/pdf/n/phosphoric-acid-fg.pdf).
In conclusion, the toxicity to Daphnia of ‘Synthetic inositol phosphate’ is expected to be comparable to that of ‘Inositol phosphates from rice bran’, with a 48 h LC0 = 50 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.