Registration Dossier
Registration Dossier
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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V, B14
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4,6-bis(octylthiomethyl)-o-cresol
- EC Number:
- 402-860-6
- EC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
- Cas Number:
- 110553-27-0
- Molecular formula:
- C25H44OS2
- IUPAC Name:
- 4,6-bis(octylthiomethyl)-o-cresol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella Typhimurium, TA 98, TA 200, TA 1535 and TA 1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- 0.3 ml of S9 fraction of liver from rats (Tif: RAlf (SPF)) induced with Aroclor 1254 and 0.7 ml of a solution f co-factors.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 20...5000 microg/plate
Concentration range in the main test (without metabolic activation): 20...5000 microg/plate - Vehicle / solvent:
- solvent: acetone
Results and discussion
Test results
- Species / strain:
- other: Salmonella Typhimurium, TA 98, TA 200, TA 1535 and TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
negative with metabolic activation
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