Registration Dossier
Registration Dossier
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EC number: 941-237-8 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In an Ames test with TA 100, TA 1535, TA 1537, TA 1538, TA 98 of Salmonella typhimurium and Escherichia coll WP2uvrA according to OECD 471 guidelines, ammonium chloride (the main constituent of the raction mass) tested up to 5000 microgram/plate, did not have an effect with and without metabolic activation. In a supporting study the same results were observed.
Ammonium chloride did not induce mutation in bacteria.
Short description of key information:
Ammonium chloride (the main constituent of the reaction mass) is found negative in an Ames test in the presence and absence of metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The registered substance has not been tested for genotoxicity, as a result, it is proposed to provide an assessment based on data read-acrossed from its main constituents.
The registered substance is an inorganic reaction mass consisting of water as well as chloride, carbonate and bicarbonate salts of ammonium and sodium. Those salts are well-known substances and relevant peer-reviewed published data are available to characterize their ecotoxicological/environmental fate/toxicological properties.
Two Ames tests are available for ammonium chloride showing that ammonium chloride did not induce mutation in bacteria. Based on the available peer-reviewed published data, sodium chloride, diammonium carbonate, ammonium hydrogencarbonate and sodium hydrogencarbonate are also negative in Ames tests. As a result, it can be concluded that the reaction mass did not induce mutation in bacteria.
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