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EC number: 939-783-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Diisotridecyl adipate: The log BCF of diisotridecyl adipate (log Pow = 13.03) was estimated to be 1.17 (BCF 14.8) using the program US EPA EPI Suite v4.00. In addition, a log BAF (upper trophic) of -0.008 (BAF = 0.982) was calculated using the method of Arnot-Gobas.
Diisotridecyl sebacate: The BCF was calculated 3.162 L/kg ww (log BCF = 0.5). In addition, a BAF was estimated to 0.935 (log BAF -0.029 - upper trophic).The low BCF/BAF values indicate a low potential of diisotridecyl adipate and diisotridecyl sebacate for bioaccumulation in aquatic organisms and therefore for the test substance Reaction product of adipic acid and sebacic acid and isotridecan-1-ol. The BCF of 14.83 is something like worst case for the components.
The BCF base-line model estimates the log BCF for the diisotridecyl adipate at 0.85 (BCF = 7.08) indicating low potential for bioaccumulation.The maximum log BCF value was calculated to be 1.39 (BCF = 24.55) . Mitigating factors like metabolism, molecule size and the water solubility were considered by the model.
Besides the low water solubility also metabolism and the molecular size reduce the log BCF as estimated by the model. Water solubility and molecular size are also discussed within the literature whether certain threshold values are suitable as cut-off criteria for indication of limited bioaccumulation. Regarding molecular size, the PBT working group on hazardous substances discussed a maximum diameter of > 17.4 Å (Comber et al., 2006). The mean maximum diameter of the test item is determined to be 25.75 Å with the lowest maximum diameter calculated for the 30 energetically preferred 3D structures of the test item being > 17.4 Å (= 18.16 Å).
The potential for accumulation of the read-across substance Bis(2 -ethylhexyl)adipate (DEHA) in aquatic organisms was examined (Felder et al., 1986) in a bioconcentration test using bluegill sunfish (Lepomis macrochirus).The test used a flow through system that maintained the concentration of DEHA at about 250 μg/L using 14C-labeled DEHA.
A steady state concentration of DEHA in the whole fish was attained by day 7. A whole fish bioconcentration factor (BCF) of 27 was reported at day 35. Daily BCFs of 3.2 to 46, 1.3 to 19, and 4.1 to 66 were reported for whole fish, fillet, and viscera samples, respectively. Following exposure to clean water, a depuration rate for DEHA of 0.26/day (t1/2 = 2.7 days) was determined.
DEHA is apparently rapidly and extensively excreted from the fish.
Takahashi (Takahashi et al., 1981) fed radio-labeled Bis(2 -ethylhexyl)adipate (DEHA) to rats and found no evidence of accumulation in any organs or tissues. After 96 hours, less than 0.14% of the administered radioactivity was found in any organ or tissue. From the results, it can be concluded that the elimination of radioactivity from tissues and organs is very rapid and there is no specific organ affinity under the experimental conditions. There was no evidence of the accumulation of radioactivity in any organs or tissues.
Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol is not expected to exhibit a significant bioaccumulation potential. The low water solubility, its molecular size and metabolism further decrease the bioaccumulation potential, which is already considered to be low based on its high log Pow value. Additionally the results on the bioconcentration studies in fish (water) and rats (feeding-study) on the read-across substance DEHA support this assumption.
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