(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Body responsible for the test

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD GUIDELINE 203 (1984) EEC Directive 84/449 (1984) - Annex V - Method C1

Deviations:

not specified

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Body responsible for the test

IUPAC Name:

Body responsible for the test

Test material form:

other: saturated solution obtained was used as such and diluted (100 % to 25 %)

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

> 0.05 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 2

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 0.05 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 3

Duration:

72 h

Dose descriptor:

LC50

Effect conc.:

> 0.05 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 4

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 0.05 mg/L

Basis for effect:

mortality (fish)

Effect concentrations 5

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 0.05 mg/L

Any other information on results incl. tables

Sublethal observations / clinical signs:

No auxiliary substance could help to solubilise the test substance.

Considering the low water-solubility of the test substance and in order to prevent impact of solid particles, the test substance was prepared as follows: a 1000 mg/L suspension was stirred for 2 hours; the substance in excess was then filtered. the saturated solution obtained was used as such and diluted (100% to 25%)

No mortality nor any abnormal behaviour were noted at any of these concentrations.

Analysis confirmed highest concentration <= limited of solubility.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

Due to its low water solubility, the test substance is not considered to be toxic to fish under the condition of the test.