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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Principles of method if other than guideline:
2 x 3 female animals received a single oral application per gavage of 2000 mg/kg bw tetraethlammonium perfluorobutanesulfonate. During a post-observeation period of 14 d , mortalites, effects on weight gain, and clinical signs were recorded. After termination of the study a gross patological examination followed.
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
content: 97.7%

Test animals

Species:
rat
Strain:
other: HsdCpb:Wu
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
2 x3 female animals - single dose of 2000 mg/kg bw
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

dose mg/kg bw toxicological result* occurrence of signs time of death mortality (%)

female

(1st) 2000                            0/3/3 10’-1h -- 0

(2nd) 2000                  0/3/3 30’-2h -- 0

* number of animals which died spontaneously and/or were sacrificed in moribund state / number of animals with signs of toxicity / total number of animals used per group

Clinical Signs

The following clinical signs were observed: decreased motility and increased salivation.

Body Weights

There were no toxicologically significant effects on body weight or body weight gain.

Gross Pathology Findings

The necropsies performed at the end of the study revealed no particular findings

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Executive summary:

This study was performed to assess the acute oral toxicity to Wistar rats of tetraethylammonium perfluorobutanesulfonate (content: 97.7%).

The test item was formulated in tap water; the administration volume was 10 ml/kg body weight.

A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities, effects on weight gain and gross pathological findings. The clinical signs were decreased motility and increased salivation.