Registration Dossier

Administrative data

Description of key information

There are no data available for Tetraethylammonium perfluorobutanesulfonate. 

Key value for chemical safety assessment

Additional information

There are no data available for Tetraethylammoniumperfluorobutanesulfonate.

A 28 d and a 90 d oral toxicity study in rats oral with potassium perfluorobutane sulfonate was evaluated and cited in the Existing Chemical Hazard Assessment Report by the Australian Government, Department of Health and aeging, NICNAS, November 2005.

In the 28 d study a No Observed Effect Level (NOEL) was established as 100 mg PFBS/kg bw/day in males in this study based on significant decreases in serum phosphorus and potassium at doses of 300 and 900 mg/kg bw/day when compared to controls. A No Observed Adverse Effect Level (NOAEL) was established as 300 mg PFBS/kg bw/day in females and males in this study based on significant increase in kidney and liver weights, respectively, in animals that received 900 mg/kg bw/day compared to controls.

In the 90 d study he NOAEL in rats was established as 200 mg PFBS/kg bw/day in this study based on necrosis in the limiting ridge of the forestomach. A significant (p = 0.05) decrease in average total protein and albumin values of 7% and 10%, respectively, was seen in males, and a significant (p = 0.01) increase in serum chloride was seen in the males. Kidney hyperplasia was also reported at 600 mg PFBS/kg bw/day. However, histopathological of the kidney by an independent expert reported that no consistent changes were seen in the kidneys and the renal effects were not secondary to treatment.

Justification for classification or non-classification

Based on the PFBS data cited in the Existing Chemical Hazard Assessment Report by the Australian Government, Department of Health and Ageing, NICNAS, November 2005, a classification is not justified.