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Diss Factsheets
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EC number: 619-880-8 | CAS number: 176972-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted in compliance with the FDA Good Laboratory Practice Regulations 21 CFR Part 58 and OECD Guideline 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Chlorohydrine
- IUPAC Name:
- Chlorohydrine
- Details on test material:
- Test Article Description: Chlorohydrine -- white powder
Date Received: January 22, 1996
Special Handling Instructions: Standard precautions
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipping
- Vehicle:
- physiological saline
- Controls:
- other: foe each animal unexposed skin area represents is its own control.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observations for responses were recorded at 60 minutes, 24, 48 and 72 hours after unwrapping and on Days 4 and 5, according to the method of Draize.
- Number of animals:
- 6 animals
Results and discussion
In vivo
- Other effects:
- Very slight to well-defined erythema with very slight to slight edema was observed 60 minutes post-unwrap, and at 48 and 72 hours and on Day 4. No necrosis was observed during the study. There was an increase in body weight of all animals during the study. The study was terminated following the Day 5 observation period.
Any other information on results incl. tables
The Primary Dermal Irritation Index is 0.5.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Based upon the observations made in the Primary Dermal Irritation Study in rabbits, the test article, Chlorohydrine is a barely perceptible irritant. The Primary Dermal Irritation Index is 0.5.
- Executive summary:
Chlorohydrine intermediate of saquinavir: Primary Dermal Irritation in Rabbits
This study was conducted in compliance with the FDA Good Laboratory Practice Regulations 21 CFR Part 58 and OECD Guideline 404.
The purpose of this study was to determine the potential irritant effects of *Chlorohydrine on the skin.
One group of New Zealand White rabbits (three males and three females) were used. The hair was clipped from the back prior to application of the test article. Each animal received 500 mg (moistened with 0.5 mL saline) of the test article at one dermal, semi occluded site. The patches were removed after four hours. Observations for responses were recorded at 60 minutes, 24, 48 and 72 hours after unwrapping and on Days 4 and 5, according to the method of Draize.
Very slight to well-defined erythema with very slight to slight edema was observed at 60 minutes post-unwrap, and at 48 and 72 hours and on Day 4. No necrosis was observed during the study. There was an increase in body weight of all animals during the study. The study was terminated following the Day 5 observation period.
Based upon the observations made in the Primary Dermal Irritation Study in rabbits, test article Chlorohydrine, is a barely perceptible dermal irritant. The Primary Dermal Irritation Index is 0.5.
Chlorohydrine was not a dermal irritant under the test conditions and thus, is not classified as irritating to the skin under EU criteria.
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