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EC number: 610-992-2 | CAS number: 53378-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 - 22 June 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Also according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium O,O-diisobutyl phosphorothioate
- EC Number:
- 610-992-2
- Cas Number:
- 53378-52-2
- Molecular formula:
- C8 H18 O3 P S . Na
- IUPAC Name:
- Sodium O,O-diisobutyl phosphorothioate
- Test material form:
- other: grease-like solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): CT 473-91
- Name: Sodium diisobutyl monothiophoshate
- CAS: 53378-52-2
- Molecular formula: C8H18O3PS.Na
- Molecular weight: 248.26
- Substance type: Amber liquid
- Physical state: Liquid
- Lot/batch No.: SPS-17220
- Storage condition of test material: Store at room temperature in the dark
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The definitive test concentrations were obtained by transferring the appropriate weight of the test compound.
- Controls: Water dilution
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Mt. Lassen Trout Farm in Red Bluff, California, USA
- Lote #: 1191
- Length at study termination (mean, range and SD): 33 ± 2 mm
- Weight at study termination (mean and range, SD): 0.42 ± 0.09 g
- Feeding during test: None
ACCLIMATION
- Acclimation period: 11 days
- Acclimation conditions (same as test or not): Yes
- Type and amount of food: Not fed in the 48 h prior to the start of the test
- Health during acclimation (any mortality observed): No
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 160-190 mg/L as CaCO3
- Test temperature:
- 12 - 13 °C
- pH:
- 7.9 - 8.3
- Dissolved oxygen:
- 7.6 - 9.2 mg/L
- Nominal and measured concentrations:
- Nominal
Range-finding test: 1, 10, 32, 56, 100 and 1000 mg/L
Definitive test: Control, 5.6, 10, 18, 32 and 56 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass vessel
- Material, size, headspace, fill volume: Glass with a capacity of 19 L. Filled with 15 L of test water.
- Aeration: No
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.28 g per liter
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 30 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 18 - 56 mg/L
- Details on results:
- - Mortality of control: None
- Other adverse effects control: None
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No
- Effect concentrations exceeding solubility of substance in test medium: No
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The present study was designed to evaluate toxicity of the test substance to fish (Oncorhynchus mykiss), the resulting 96 h LC50 was 30 mg/L and the NOEC was 18 mg/L (as nominal concentrations).
- Executive summary:
In a 96-h acute toxicity study conducted according to OECD TG 203 and GLP principles, rainbow trout (Oncorhynchus mykiss) were exposed to the test material at nominal concentrations of 0 (water control), 5.6, 10, 18, 32 and 56 mg/L under static conditions. The NOEC value was 18 mg/L and the LC50 is 30 mg/L (as nominal concentrations). The present toxicity study is classified as reliable without restrictions since it satisfies the guideline requirements for the fish acute toxicity study (OECD 203). However, water concentrations of test compound were not measured.
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