Registration Dossier
Registration Dossier
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EC number: 203-938-0 | CAS number: 112-13-0
Endpoint summary
Administrative data
Description of key information
Acid chlorides are considered corrosive to mucus membranes. "Study(ies) do not generally need to be conducted if the substance is classified as corrosive to the skin (Annex VIII 8.5)." In addition, the registered substance is an on-site isolated intermediate. Per the Guidance on Intermediates, "If the manufacturer confirms in his IUCLID registration dossier that the on-site isolated intermediate is manufactured and used under strictly controlled conditions (see section 2.1), the information requirements on the substance intrinsic properties (physicochemical, human health and environment properties) are reduced to already available data (e.g. information he holds himself or that he can obtain from other sources) and only study summaries have to be submitted even if a full study report is available (Article 17) (see 2.2)."
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Additional information
Justification for classification or non-classification
Acid chlorides are considered corrosive to mucus membranes. "Study(ies) do not generally need to be conducted if the substance is classified as corrosive to the skin (Annex VIII 8.5)." In addition, the registered substance is an on-site isolated intermediate. Per the Guidance on Intermediates, "If the manufacturer confirms in his IUCLID registration dossier that the on-site isolated intermediate is manufactured and used under strictly controlled conditions (see section 2.1), the information requirements on the substance intrinsic properties (physicochemical, human health and environment properties) are reduced to already available data (e.g. information he holds himself or that he can obtain from other sources) and only study summaries have to be submitted even if a full study report is available (Article 17) (see 2.2)."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
