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Diss Factsheets
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EC number: 612-957-7 | CAS number: 62211-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 14-AUG-2001 to 19-SEP-2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study has been performed in compliance with the Swiss Ordinance relating to Good Laboratory Practice, adopted February 2nd, 2000 [RS 813.01 6.51. This Ordinance is based on the OECD Principles of Good Laboratory Practice, as revised in 1997 and adopted November 26th, 1997 by decision of the OECD Council [C(97)186/Final]. These procedures were consistent with Good Laboratory Practice regulations specified by regulatory authorities throughout the European Community, the United States (EPA and FDA), and Japan (MHW, MAFF and MITI).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Acetylfuranoside
- IUPAC Name:
- Acetylfuranoside
- Details on test material:
- Description: white powder
Stability of test item Stable under storage conditions
Expiry date 08- J U N-2002
Storage conditions: In the original container, in the refrigerator (range of 2-8 OC), away from direct sunlight. The container was purged with nitrogen after use.
Safety precautions: Routine hygienic procedures were used to ensure the health and safety of the personnel.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped with an electric clipper
- Vehicle:
- water
- Controls:
- other: untreated unclipped right flank of the test animal
- Duration of treatment / exposure:
- four hours
- Observation period:
- The skin reactions (erythema and eschar, as well as oedema formation) were evaluated at 1, 24, 48 and 72 hours after removal of the dressing and test item.
- Number of animals:
- three
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of three animals
- Time point:
- other: 1 to 72 hours
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- other: 1 to 72 hours
- Score:
- 0
Any other information on results incl. tables
VIABILITY/MORTALITY/CLINICAL SIGNS
No clinical signs of systemic toxicity were observed in the animals during the study and no mortality occurred.
IRRITATION
The test item did not elicit any skin reactions at the application site of any animal at any of the observation times (all scores0).The individual mean score for erythema/eschar and oedema for each of the three animals was therefore0.
COLORATION
No staining by the test item on the treated skin was observed.
CORROSION
Noirreversible alterations of the treated skin were observed nor were corrosive effects evident on the skin.
BODY WEIGHTS
The body weights of all rabbits were considered to be within the normal range of variability.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based upon the referred classification criteria (EEC Commission Directive 93/21/EEC of
April 27, 1993), ACETYLFURANOSIDE is considered to be “not irritating” to rabbit skin. - Executive summary:
To assess the primary skin irritation potential of ACETYLFURANOSIDE, a primary skin irritation study was performed in three (one male and two females) young adult New Zealand White rabbits.
The fur of the left flank was clipped and 0.5 g of ACETYLFURANOSIDE was applied epicutaneously to an area of approximately 6 cm2and then covered with a semi-occlusive dressing for approximately four hours. The skin reactions (erythema and eschar, as well as oedema formation) were evaluated at 1, 24, 48 and 72 hours after removal of the dressing and test item.
The test item did not elicit any skin reactions at the application site of any animal at any of the observation times (all scores 0). The individual mean score for erythema/eschar and oedema for each of the three animals was therefore 0.
The test item caused no staining of the treated skin.
No corrosive effects were noted on the treated skin of any animal at any measuring interval.
Following evaluation of the experimental data according to the EEC classification criteria, ACETYLFURANOSIDE is classified as "not irritating" to rabbit skin.
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