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Diss Factsheets
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EC number: 203-219-1 | CAS number: 104-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted similarly to OECD Guideline 401 with minor deviations: certificate of analysis not included, few details on test animals and environmental conditions, no data on number of animals showing signs of toxicity and pathological findings.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no data on age and source of animals; no data on housing and environmental conditions, number of animals showing signs of toxicity and pathological findings
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Nonan-4-olide
- EC Number:
- 203-219-1
- EC Name:
- Nonan-4-olide
- Cas Number:
- 104-61-0
- Molecular formula:
- C9H16O2
- IUPAC Name:
- 5-pentyloxolan-2-one
- Details on test material:
- - Name of test material (as cited in study report): Compound No. 72-41
- Source: Research Institute for Fragrance Materials, Inc., New Jersey, USA
- Physical state: Clear liquid
- Date of receipt: 11 April, 1972
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-250 g
- Fasting period before study (minimum): 16 h
- Food and water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 4000, 5000, 6250, 7800 and 9700 mg/kg bw
- No. of animals per sex per dose:
- 10 males/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observations for mortality were made at 1 and 6 h after dosing and daily thereafter for 14 days.
- Necropsy of survivors performed: Yes - Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 800 - 7 400
- Mortality:
- - Deaths occurred overnight to two days following administration of the test material.
- Mortalities in rats were 0, 30, 40, 80 and 100 % at 4000, 5000, 6250, 7800 and 9700 mg/kg bw, respectively. - Clinical signs:
- other: Piloerection and lethargy
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of γ-Nonalactone is higher than 5000 mg/kg bw in male rats therefore it is not classified according to the Directive 67/548/EEC and of the Regulation (EC) No. 1272/2008 (CLP).
- Executive summary:
In an acute oral toxicity study performed similarly to OECD test Guideline No. 401, groups of Wistar rats (10 males/dose) were given a single oral dose of γ-Nonalactone at 4000, 5000, 6250, 7800 or 9700 mg/kg bw. Animals were then observed for mortality at 1 and 6 h after dosing and daily thereafter for 14 days. Gross necropsies were performed on all survivors.
Mortalities in rats were 0, 30, 40, 80 and 100 % at 4000, 5000, 6250, 7800 and 9700 mg/kg bw, respectively. Clinical signs noted were piloerection and lethargy.
Oral LD50 Males = 6600 mg/kg bw (5800-7400).
The oral LD50 of γ-Nonalactone is higher than 5000 mg/kg bw in male rats therefore it is not classified according to the Directive 67/548/EEC and the Regulation (EC) No. 1272 /2008 (CLP). This study is considered as acceptable and satisfies the requirement for acute oral toxicity endpoint.
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