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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 264-120-7 | CAS number: 63393-96-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only summary of data available but scientifically acceptable published data from an acknowledged source (EU Risk Assessment Report) (Data suitable for read-across).
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report dimethyldioctadecylammonium chloride
- Author:
- European Chemicals Bureau, Institute for Health and Consumer Protection
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Metabolism of cutaneously applied surfactants.
- Author:
- Drotman R.B.
- Year:
- 1 977
- Bibliographic source:
- Cutaneous Toxicity, 3, 95-109
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- The 14C-labelled test substance was applied to the back of 4 rabbits. Radioactivity at the application site, in urine, faeces, exhaled carbon dioxide, other skin and cage wash was determined over a 72 hour period.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyldioctadecylammonium chloride
- EC Number:
- 203-508-2
- EC Name:
- Dimethyldioctadecylammonium chloride
- Cas Number:
- 107-64-2
- Molecular formula:
- C38H80N.Cl
- IUPAC Name:
- N,N-dimethyl-N-octadecyloctadecan-1-aminium chloride
- Details on test material:
- - Name of test material (as cited in study report): Dioctadecyldimethylammonium chloride (DODMAC)
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- not specified
- Details on exposure:
- TEST SITE
- Area of exposure: on the back, 5-8 cm area - Duration and frequency of treatment / exposure:
- single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg
- No. of animals per sex per dose / concentration:
- 4
- Control animals:
- no
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, faeces, skin at the application site, other skin, cage washes, exhaled carbon dioxide
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Most of the radioactivity remained at the site of application (88 ± 2.3%).
- Details on distribution in tissues:
- Only traces of radioactivity were detected at other skin sites (0.2%).
- Details on excretion:
- Only traces of administered radioactivity were detected over a 72 h-period in urine (0.15 %), faeces (0.16 %), exhaled carbon dioxide (0.27 %) and cage wash (0.3%).
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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