Registration Dossier
Registration Dossier
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EC number: 252-328-0 | CAS number: 35037-73-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Small cellulose lobes (2.5 x 2.5 cm²) with ca. 500 µl of 4-trifluoromethoxyphenyl isocyanate was applied to the inner surface of one ear per animal; exposure time was 1 or 2 hours. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- p-(trifluoromethoxy)phenyl isocyanate
- EC Number:
- 252-328-0
- EC Name:
- p-(trifluoromethoxy)phenyl isocyanate
- Cas Number:
- 35037-73-1
- Molecular formula:
- C8H4F3NO2
- IUPAC Name:
- 1-isocyanato-4-(trifluoromethoxy)benzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1 or 2 hours
- Observation period:
- 7 days
- Number of animals:
- 1 animal/exposure time
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 6, 7 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 6, 7 days
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 6, 7 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 6, 7 days
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
Any other information on results incl. tables
Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found. 4-trifluoromethoxyphenyl isocyanate is irritating.
- Executive summary:
Small cellulose lobes (2.5 x 2.5 cm²) with ca. 500 µL of 4-trifluoromethoxyphenyl isocyanate was applied to the inner surface of one ear per animal; exposure time was 1or 2 hours. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.
Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found. 4-trifluoromethoxyphenyl isocyanate is irritating.
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