Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
ADSORPTIION DESORPTION BEHAVIOUR
[14C]-Octopriox Adsorption Desorption test according OECD 106
As Octopirox exists in an ionic form at higher pH it can sorb not via van der Waal forces but also by ionic interactions (e.g ion pair formation, cation exchange). So far no mechanistic model exists to estimate the sorption behaviour of these substances. Therefore measurements are warranted to address the sorption to solid phases reliably. Sorption was measured in three different soils, one sediment and one secondary sludge. The Freundlich isotherms for the different matrices are non-linear (1/n < 1). As the lowest tested concentration is used for the exposure assessment, Table 5.4-1 below lists the Kd and Koc at that concentration which allows to judge the sorption behaviour without a calculation excerise using the Freundlich isotherm.
Table 5.4 Sorption behaviour of [14C]-Octopirox to different solid matrices
SOIL |
|
% OC |
|
% Clay |
|
CEC |
Kd (L/kg) |
|
Koc (L/kg) |
Cranfield 164 |
|
3.7 |
|
28 |
|
22.8 |
4885 |
|
132027 |
|
|
|
|
|
|
||||
Cranfield 277 |
|
2.7 |
|
57 |
|
22.4 |
4800 |
|
177778 |
|
|
|
|
|
|
||||
Cranfield 299 |
|
2.9 |
|
26 |
|
14.9 |
4172 |
|
143862 |
|
|
|
|
|
|
||||
mean |
|
3.1 |
|
34 |
|
15.3 |
4619 |
|
149000 |
|
|
|
|
||||||
SEDIMENT |
|
|
|
|
|
|
|
|
|
SW |
|
6.2 |
|
25 |
|
21.7 |
3782 |
|
61000 |
|
|
|
|
|
|
||||
|
|
|
|
||||||
SLUDGE |
|
|
|
|
|
|
|
|
|
secondary (activated) |
|
37.5 |
|
59 |
|
96 |
1477 |
|
3939 |
|
|
|
|
|
|
||||
|
|
|
|
The Koc values from the OECD 106 study were used in the Environmental exposure assessment of Octopirox carried out with the EUSES model. As EUSES assigns certain percentages of organic carbon (OC) to the different compartments, Kd values for EUSES were calculate from the available Koc as given in the table 5.4-2
Table 5.4-2 Recalculation of Sorption constants for Octopirox to values which can be used in the EUSES Exposure assessment
|
OECD106 results at 10 µg/L Octopirox |
EUSES STANDARD VALUES %OC and Kd related to Koc |
|||
SOIL |
|
|
|
|
|
|
% OC |
Koc (L/kg) average |
% OC |
Kd (L/kg) EUSES |
EUSES Term for |
Cranfield 164 |
3.7 |
132027 |
|
|
|
Cranfield 277 |
2.7 |
177778 |
|
|
|
Cranfield 299 |
2.9 |
143862 |
|
|
|
mean |
3.1 |
149000 (based on mean values Kd & OC %) |
2 |
2980 |
SOIL |
SEDIMENT |
|
|
|
|
|
SW |
6.2 |
61000 |
5 |
3050 |
SEDIMENT |
SLUDGE |
|
|
|
|
|
secondary (activated) |
37.5 |
3939 |
37 |
1457 |
ACTIV. SLUDGE |
Octopirox considerably sorbs to solid matrices especially to soils and sediment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.