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EC number: 216-087-5 | CAS number: 1493-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 20 July 2012 to 26 September 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2010-08-25
- Type of method:
- dynamic method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 2.4 hPa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 3.2 hPa
- Key result
- Temp.:
- 50 °C
- Vapour pressure:
- 12.9 hPa
- Key result
- Transition / decomposition:
- no
- Conclusions:
- The vapour pressure of the test item at 20°C is 2.4 hPa.
The vapour pressure of the test item at 25°C is 3.2hPa.
The vapour pressure of the test item at 50°C is 12.9 hPa. Based on these results the test item can be considered as low volatile. - Executive summary:
The vapour pressure was carried out using a procedure designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 104 of the OECD Guidelines for Testing Chemicals and GLP. No deviations from the Guidelines was observed.
Before the determination of the test item vapour pressure, a DSC-measurement was performed to determine the thermal stability of the test item. The test item was stable until 300°C.
Then the vapour pressure test with the dynamic method was performed. The test item is filled in a storage tank, which is at the bottom of the apparatus and it is stirred with a magnetic stirrer. The thermo dynamic equilibrium is reached within a Cottrell pump. The Cottrell pump is located shortly above the liquid level. After the vapour and liquid phase had passed the Cottrell pump, both the liquid and the vapour phase condensate are returned into the storage tank.At equilibrium, the vapour pressure of a pure substance is a function of temperature only (Antoine equation). From the measured data points of the vapour pressure curve (vapour pressure in Pa versus inverse temperature in 1/K), the constants A, B and C of the Antoine equation can be derived by regression. With these constants and the Antoine equation, the vapour pressure of the test item at 20, 25 and 50°C was calculated.
The vapour pressure of the test item at 20°C is 2.4 hPa.
The vapour pressure of the test item at 25°C is 3.2hPa.
The vapour pressure of the test item at 50°C is 12.9 hPa. Based on these results, the test item can be considered as low volatile.
Reference
Thermal stability test:
No effects could be observed up to a maximum temperature of 300 °C. From approximately 260 °C up to 300 °C the base line is a bit noisy, which is caused by increasing pressure.
Dynamic method:
The vapour pressure are measured in the temperature range of 78 to 164 °C. The measured vapour pressure values together with the measured temperatures are listed in the following table:
No. |
Temperature / °C |
Vapour pressure / hPa |
Remark |
1 |
78.17 |
50 |
measured up |
2 |
96.21 |
100 |
measured up |
3 |
115.15 |
200 |
measured up |
4 |
126.72 |
300 |
measured up |
5 |
135.29 |
400 |
measured up |
6 |
157.63 |
800 |
measured up |
7 |
163.51 |
950 |
measured up |
8 |
155.53 |
750 |
measured down |
9 |
142.37 |
500 |
measured down |
10 |
121.44 |
250 |
measured down |
From the measured data points of the vapour pressure curve (vapour pressure in Pa versus inverse temperature in 1/K), the constants A, B and C of the Antoine equation can be derived by regression of the data points to:
A = 10.2626
B = -2311.14
C = 273.15.
Coefficient of determination: R2= 0.9998
The vapour pressure of the test item calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC 440/2008 Method A.4.Vapour Pressure are shown in the following table:
Temperature / °C |
Vapour pressure / hPa |
20 |
2.4 |
25 |
3.2 |
50 |
12.9 |
Description of key information
Experimental value of vapour pressure: 2.4 hPa (at 20°C), 3.2 hPa (at 25°C), 12.9 hPa (50°C). Based on these results, the test item can be considered as low volatile.
Database data: 10 hPa at 50°C (GESTIS), 0.133 hPa at 25°C (SRC)
Key value for chemical safety assessment
- Vapour pressure:
- 2.4 hPa
- at the temperature of:
- 20 °C
Additional information
The key study was carried out using a procedure designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 104 of the OECD Guidelines for Testing Chemicals and GLP. No deviations from the Guidelines was observed.Before the determination of the test item vapour pressure, a DSC-measurement was performed to determine the thermal stability of the test item. The test item was stable until 300°C.
The key study results for the vapour pressure are 2.4 hPa (at 20°C), 3.2 hPa (at 25°C), 12.9 hPa (50°C). Based on these results, the test item can be considered as low volatile.
The data from the database GESTIS is consistent with this experimental result.
The data from the database SRC was obtained with extrapolated data from various data of unknown origin. This can explain the difference with the result of the key study.
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