Registration Dossier
Registration Dossier
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EC number: 700-768-3 | CAS number: 1285610-71-0
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity (LD50) was found to be greater than 2000 mg/kg (Bioassay, 10A0590/11X168, 2012)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In an acute oral toxicity study performed according to the Acute Toxic Class method (GLP, OECD 423), 2000 mg/kg bw of the undiluted test item were administered to two test groups of three fasted Wistar rats each by gavage. No mortality occurred. The following test substance-related clinical observations were recorded in both test groups: impaired general state, dyspnea, piloerection, exsiccosis and reduced feces. The mean body weight of one female of the first test group did not adequately increase throughout the first observation week but increased normally in the second post-exposure observation week. The mean body weight of the second test group increased within the normal range throughout the study period. There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period. The acute oral LD50 was calculated to be > 2000 mg/kg bw.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data is reliable and suitable for the purpose of classification under Directive 67/548/EEC. Based on the data, classification for acute toxicity is not warranted under Directive 67/548/EEC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the data, classification for acute toxicity is not warranted under Regulation (EC) No.1272/2008.
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