Registration Dossier
Registration Dossier
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EC number: 236-690-7 | CAS number: 13464-97-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Limited data are available due to waiving. Hydrazine mono-nitrate is classified under a group entry for hydrazine salts. CLP classification: Acute oral tox 3, Acute dermal tox 3, Acute inhalation tox 3, Skin sens 1, Carc 1B.
Short description of key information on absorption rate:
Hydrazine mono nitrate is classified as a skin sensitiser and as corrosive.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 100
Additional information
No specific data on toxickoinetics are available. Interpretation of the existing toxicological data indicates that hydrazine mono-nitrate is absorbed via the skin, due to the sensitisation observed in this category of substances as exemplified by the classification (hydrazine salts). The elucidation of absorption via the oral and inhalatory routes, distribution, metabolism and excretion has not been possible due to waiving of data.
Discussion on bioaccumulation potential result:
No specific data on toxickoinetics are available. Interpretation of the existing toxicological data indicates that hydrazine mono-nitrate is absorbed via the skin, due to the sensitisation observed in this category of substances as exemplified by the classification (hydrazine salts). The elucidation of absorption via the oral and inhalatory routes, distribution, metabolism and excretion has not been possible due to waiving of data.
Discussion on absorption rate:
The rate and extent of absorption cannot be elucidated from the data available. Hydrazine mono-nitrate is classifiable as a skin sensitiser. Therefore, some absorption must occur to induce sensitisation. It is likely that the skin barrier will be compromised by the irritation/sensitisation observed following application of hydrazine mono-nitrate, and that some absorption via this route will occur. No data are available on exposure via inhalation. A default of 100% has been calculated, due to the irritant properties of hydrazine mono-nitrate.
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