Registration Dossier
Registration Dossier
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EC number: 601-672-3 | CAS number: 120118-14-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
- EC Number:
- 601-672-3
- Cas Number:
- 120118-14-1
- Molecular formula:
- C11H8ClN3
- IUPAC Name:
- 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Examinations: immediately before the application and 60 min, 24 h, 48 h and 72 h after patch removal
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Remarks:
- and edema score
- Basis:
- mean
- Time point:
- other: 60 min, 24 h, 48 h, 72 h after patch removal
- Remarks on result:
- other: none of the 3 animals showed any substance related lesions
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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